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Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis
Background. Inflammation plays a crucial role in the development and progression of osteoarthritis (OA). Interleukin-15 (IL-15) is a well-known proinflammatory cytokine. Objective. We aimed at evaluating the relationship between serum IL-15 levels and the severity of pain as well as radiographic pro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774978/ https://www.ncbi.nlm.nih.gov/pubmed/24167367 http://dx.doi.org/10.1155/2013/176278 |
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author | Sun, Jian-Min Sun, Liang-Zhi Liu, Jun Su, Bao-hui Shi, Lin |
author_facet | Sun, Jian-Min Sun, Liang-Zhi Liu, Jun Su, Bao-hui Shi, Lin |
author_sort | Sun, Jian-Min |
collection | PubMed |
description | Background. Inflammation plays a crucial role in the development and progression of osteoarthritis (OA). Interleukin-15 (IL-15) is a well-known proinflammatory cytokine. Objective. We aimed at evaluating the relationship between serum IL-15 levels and the severity of pain as well as radiographic progression in patients with knee OA. Methods. Two hundred and twenty-six OA patients and 106 controls were enrolled in this study. The symptomatic/radiological severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index- (WOMAC-)pain scores/Kellgren-Lawrence (KL) grading system. Serum IL-15 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results. Serum IL-15 levels were significantly higher in OA patients compared with controls. Serum IL-15 levels were independently and positively correlated with WOMAC-pain scores but not KL grades in OA patients. Conclusions. We demonstrated that increased serum IL-15 levels were independently correlated with self-reported greater pain in knee OA patients. These results suggest that IL-15 might play a crucial role in the pathogenesis of OA related pain and therapeutic interventions by blocking IL-15 signaling pathways to delay the degenerative process of OA related pain which warrants further investigations. |
format | Online Article Text |
id | pubmed-3774978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37749782013-10-01 Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis Sun, Jian-Min Sun, Liang-Zhi Liu, Jun Su, Bao-hui Shi, Lin Dis Markers Research Article Background. Inflammation plays a crucial role in the development and progression of osteoarthritis (OA). Interleukin-15 (IL-15) is a well-known proinflammatory cytokine. Objective. We aimed at evaluating the relationship between serum IL-15 levels and the severity of pain as well as radiographic progression in patients with knee OA. Methods. Two hundred and twenty-six OA patients and 106 controls were enrolled in this study. The symptomatic/radiological severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index- (WOMAC-)pain scores/Kellgren-Lawrence (KL) grading system. Serum IL-15 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results. Serum IL-15 levels were significantly higher in OA patients compared with controls. Serum IL-15 levels were independently and positively correlated with WOMAC-pain scores but not KL grades in OA patients. Conclusions. We demonstrated that increased serum IL-15 levels were independently correlated with self-reported greater pain in knee OA patients. These results suggest that IL-15 might play a crucial role in the pathogenesis of OA related pain and therapeutic interventions by blocking IL-15 signaling pathways to delay the degenerative process of OA related pain which warrants further investigations. Hindawi Publishing Corporation 2013 2013-09-02 /pmc/articles/PMC3774978/ /pubmed/24167367 http://dx.doi.org/10.1155/2013/176278 Text en Copyright © 2013 Jian-Min Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sun, Jian-Min Sun, Liang-Zhi Liu, Jun Su, Bao-hui Shi, Lin Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis |
title | Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis |
title_full | Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis |
title_fullStr | Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis |
title_full_unstemmed | Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis |
title_short | Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis |
title_sort | serum interleukin-15 levels are associated with severity of pain in patients with knee osteoarthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774978/ https://www.ncbi.nlm.nih.gov/pubmed/24167367 http://dx.doi.org/10.1155/2013/176278 |
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