Cargando…

Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders

BACKGROUND: The prevalence of metabolic syndrome (MS) is found to be higher in patients with depression than in the general population. As there is lack of data from India, this study aimed to assess the prevalence of MS in patients with depression who had never been treated with antidepressants for...

Descripción completa

Detalles Bibliográficos
Autores principales: Grover, Sandeep, Nebhinani, Naresh, Chakrabarti, Subho, Avasthi, Ajit, Kulhara, Parmanand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775049/
https://www.ncbi.nlm.nih.gov/pubmed/24049228
http://dx.doi.org/10.4103/0253-7176.116247
_version_ 1782284567461232640
author Grover, Sandeep
Nebhinani, Naresh
Chakrabarti, Subho
Avasthi, Ajit
Kulhara, Parmanand
author_facet Grover, Sandeep
Nebhinani, Naresh
Chakrabarti, Subho
Avasthi, Ajit
Kulhara, Parmanand
author_sort Grover, Sandeep
collection PubMed
description BACKGROUND: The prevalence of metabolic syndrome (MS) is found to be higher in patients with depression than in the general population. As there is lack of data from India, this study aimed to assess the prevalence of MS in patients with depression who had never been treated with antidepressants for their depressive disorder and compare the same with a matched group of healthy controls. MATERIALS AND METHODS: Forty-three drug-naïve patients with depressive disorders and 43 age- and gender-matched healthy controls were assessed for the prevalence of MS as per the consensus definition. RESULTS: The prevalence of MS in patients with depression was 37.2% and was significantly higher than that seen in the healthy controls (16.3%). Increased waist circumference was the most common abnormality in both the study groups. Compared to healthy controls, a significantly higher proportion of patients with depression had abnormal waist circumference, systolic blood pressure, or high blood pressure. Besides 16 patients with depressive disorders having MS, another 53.5% of patients fulfilled one or two criteria of MS. None of the sociodemographic variables was associated with development of MS in patients with depression. CONCLUSIONS: Slightly more than one-third of depressed patients who are drug-naïve have MS and this prevalence rate is significantly higher than in healthy controls.
format Online
Article
Text
id pubmed-3775049
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37750492013-09-18 Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders Grover, Sandeep Nebhinani, Naresh Chakrabarti, Subho Avasthi, Ajit Kulhara, Parmanand Indian J Psychol Med Original Article BACKGROUND: The prevalence of metabolic syndrome (MS) is found to be higher in patients with depression than in the general population. As there is lack of data from India, this study aimed to assess the prevalence of MS in patients with depression who had never been treated with antidepressants for their depressive disorder and compare the same with a matched group of healthy controls. MATERIALS AND METHODS: Forty-three drug-naïve patients with depressive disorders and 43 age- and gender-matched healthy controls were assessed for the prevalence of MS as per the consensus definition. RESULTS: The prevalence of MS in patients with depression was 37.2% and was significantly higher than that seen in the healthy controls (16.3%). Increased waist circumference was the most common abnormality in both the study groups. Compared to healthy controls, a significantly higher proportion of patients with depression had abnormal waist circumference, systolic blood pressure, or high blood pressure. Besides 16 patients with depressive disorders having MS, another 53.5% of patients fulfilled one or two criteria of MS. None of the sociodemographic variables was associated with development of MS in patients with depression. CONCLUSIONS: Slightly more than one-third of depressed patients who are drug-naïve have MS and this prevalence rate is significantly higher than in healthy controls. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3775049/ /pubmed/24049228 http://dx.doi.org/10.4103/0253-7176.116247 Text en Copyright: © Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Grover, Sandeep
Nebhinani, Naresh
Chakrabarti, Subho
Avasthi, Ajit
Kulhara, Parmanand
Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders
title Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders
title_full Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders
title_fullStr Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders
title_full_unstemmed Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders
title_short Metabolic Syndrome in Drug-naïve Patients with Depressive Disorders
title_sort metabolic syndrome in drug-naïve patients with depressive disorders
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775049/
https://www.ncbi.nlm.nih.gov/pubmed/24049228
http://dx.doi.org/10.4103/0253-7176.116247
work_keys_str_mv AT groversandeep metabolicsyndromeindrugnaivepatientswithdepressivedisorders
AT nebhinaninaresh metabolicsyndromeindrugnaivepatientswithdepressivedisorders
AT chakrabartisubho metabolicsyndromeindrugnaivepatientswithdepressivedisorders
AT avasthiajit metabolicsyndromeindrugnaivepatientswithdepressivedisorders
AT kulharaparmanand metabolicsyndromeindrugnaivepatientswithdepressivedisorders