Cargando…

Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction

Background: The association between increased arterial stiffness and left ventricular diastolic dysfunction (LVDD) may be influenced by left ventricular performance. P wave dispersion is not only a significant determinant of left ventricular performance, but is also correlated with LVDD. This study...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsai, Wei-Chung, Lee, Kun-Tai, Kuo, Hsuan-Fu, Tang, Wei-Hua, Jhuo, Shih-Jie, Chu, Chih-Sheng, Lin, Tsung-Hsien, Hsu, Po-Chao, Lin, Ming-Yen, Lin, Feng-Hsien, Su, Ho-Ming, Voon, Wen-Chol, Lai, Wen-Ter, Sheu, Sheng-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775098/
https://www.ncbi.nlm.nih.gov/pubmed/24046515
http://dx.doi.org/10.7150/ijms.5753
_version_ 1782284578855059456
author Tsai, Wei-Chung
Lee, Kun-Tai
Kuo, Hsuan-Fu
Tang, Wei-Hua
Jhuo, Shih-Jie
Chu, Chih-Sheng
Lin, Tsung-Hsien
Hsu, Po-Chao
Lin, Ming-Yen
Lin, Feng-Hsien
Su, Ho-Ming
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
author_facet Tsai, Wei-Chung
Lee, Kun-Tai
Kuo, Hsuan-Fu
Tang, Wei-Hua
Jhuo, Shih-Jie
Chu, Chih-Sheng
Lin, Tsung-Hsien
Hsu, Po-Chao
Lin, Ming-Yen
Lin, Feng-Hsien
Su, Ho-Ming
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
author_sort Tsai, Wei-Chung
collection PubMed
description Background: The association between increased arterial stiffness and left ventricular diastolic dysfunction (LVDD) may be influenced by left ventricular performance. P wave dispersion is not only a significant determinant of left ventricular performance, but is also correlated with LVDD. This study is designed to compare left ventricular diastolic function among patients divided by brachial-ankle pulse wave velocity (baPWV) and corrected P wave dispersion (PWDC) and assess whether the combination of baPWV and PWDC can predict LVDD more accurately. Methods: This cross-sectional study enrolled 270 patients and classified them into four groups according to the median values of baPWV and PWDC. LVDD was defined as impaired relaxation and pseudonormal/restrictive mitral inflow patterns. Results: The ratio of transmitral E wave velocity to early diastolic mitral annulus velocity (E/Ea) was higher in group with higher baPWV and PWDC than in the other groups (all p <0.001). The prevalence of LVDD was higher in group with higher baPWV and PWDC than in the two groups with lower baPWV (p ≤ 0.001). The baPWV and PWDC were correlated with E/Ea and LVDD in multivariate analysis (p ≤ 0.030). The addition of baPWV and PWDC to a clinical mode could significantly improve the R square in prediction of E/Ea and C statistic and integrated discrimination index in prediction of LVDD (p ≤ 0.010). Conclusions: This study showed increased baPWV and PWDC were correlated with high E/Ea and LVDD. The addition of baPWV and PWDC to a clinical model improved the prediction of high E/Ea and LVDD. Screening patients by means of baPWV and PWDC might help identify the high risk group of elevated left ventricular filling pressure and LVDD.
format Online
Article
Text
id pubmed-3775098
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-37750982013-09-17 Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction Tsai, Wei-Chung Lee, Kun-Tai Kuo, Hsuan-Fu Tang, Wei-Hua Jhuo, Shih-Jie Chu, Chih-Sheng Lin, Tsung-Hsien Hsu, Po-Chao Lin, Ming-Yen Lin, Feng-Hsien Su, Ho-Ming Voon, Wen-Chol Lai, Wen-Ter Sheu, Sheng-Hsiung Int J Med Sci Research Paper Background: The association between increased arterial stiffness and left ventricular diastolic dysfunction (LVDD) may be influenced by left ventricular performance. P wave dispersion is not only a significant determinant of left ventricular performance, but is also correlated with LVDD. This study is designed to compare left ventricular diastolic function among patients divided by brachial-ankle pulse wave velocity (baPWV) and corrected P wave dispersion (PWDC) and assess whether the combination of baPWV and PWDC can predict LVDD more accurately. Methods: This cross-sectional study enrolled 270 patients and classified them into four groups according to the median values of baPWV and PWDC. LVDD was defined as impaired relaxation and pseudonormal/restrictive mitral inflow patterns. Results: The ratio of transmitral E wave velocity to early diastolic mitral annulus velocity (E/Ea) was higher in group with higher baPWV and PWDC than in the other groups (all p <0.001). The prevalence of LVDD was higher in group with higher baPWV and PWDC than in the two groups with lower baPWV (p ≤ 0.001). The baPWV and PWDC were correlated with E/Ea and LVDD in multivariate analysis (p ≤ 0.030). The addition of baPWV and PWDC to a clinical mode could significantly improve the R square in prediction of E/Ea and C statistic and integrated discrimination index in prediction of LVDD (p ≤ 0.010). Conclusions: This study showed increased baPWV and PWDC were correlated with high E/Ea and LVDD. The addition of baPWV and PWDC to a clinical model improved the prediction of high E/Ea and LVDD. Screening patients by means of baPWV and PWDC might help identify the high risk group of elevated left ventricular filling pressure and LVDD. Ivyspring International Publisher 2013-08-26 /pmc/articles/PMC3775098/ /pubmed/24046515 http://dx.doi.org/10.7150/ijms.5753 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Tsai, Wei-Chung
Lee, Kun-Tai
Kuo, Hsuan-Fu
Tang, Wei-Hua
Jhuo, Shih-Jie
Chu, Chih-Sheng
Lin, Tsung-Hsien
Hsu, Po-Chao
Lin, Ming-Yen
Lin, Feng-Hsien
Su, Ho-Ming
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction
title Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction
title_full Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction
title_fullStr Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction
title_full_unstemmed Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction
title_short Association of Increased Arterial Stiffness and P Wave Dispersion with Left Ventricular Diastolic Dysfunction
title_sort association of increased arterial stiffness and p wave dispersion with left ventricular diastolic dysfunction
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775098/
https://www.ncbi.nlm.nih.gov/pubmed/24046515
http://dx.doi.org/10.7150/ijms.5753
work_keys_str_mv AT tsaiweichung associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT leekuntai associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT kuohsuanfu associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT tangweihua associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT jhuoshihjie associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT chuchihsheng associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT lintsunghsien associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT hsupochao associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT linmingyen associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT linfenghsien associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT suhoming associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT voonwenchol associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT laiwenter associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction
AT sheushenghsiung associationofincreasedarterialstiffnessandpwavedispersionwithleftventriculardiastolicdysfunction