(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood–brain barrier, and not by MRP1 and BCRP

INTRODUCTION: Positron emission tomography (PET) with [(11)C]verapamil, either in racemic form or in form of the (R)-enantiomer, has been used to measure the functional activity of the adenosine triphosphate-binding cassette (ABC) transporter P-glycoprotein (Pgp) at the blood–brain barrier (BBB). Th...

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Detalles Bibliográficos
Autores principales: Römermann, Kerstin, Wanek, Thomas, Bankstahl, Marion, Bankstahl, Jens P., Fedrowitz, Maren, Müller, Markus, Löscher, Wolfgang, Kuntner, Claudia, Langer, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775124/
https://www.ncbi.nlm.nih.gov/pubmed/23845421
http://dx.doi.org/10.1016/j.nucmedbio.2013.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775124/
https://www.ncbi.nlm.nih.gov/pubmed/23845421
http://dx.doi.org/10.1016/j.nucmedbio.2013.05.012

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