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Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775240/ https://www.ncbi.nlm.nih.gov/pubmed/23912329 http://dx.doi.org/10.3390/nu5083022 |
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author | Castiglioni, Sara Cazzaniga, Alessandra Albisetti, Walter Maier, Jeanette A. M. |
author_facet | Castiglioni, Sara Cazzaniga, Alessandra Albisetti, Walter Maier, Jeanette A. M. |
author_sort | Castiglioni, Sara |
collection | PubMed |
description | A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity. |
format | Online Article Text |
id | pubmed-3775240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37752402013-09-17 Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions Castiglioni, Sara Cazzaniga, Alessandra Albisetti, Walter Maier, Jeanette A. M. Nutrients Review A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity. MDPI 2013-07-31 /pmc/articles/PMC3775240/ /pubmed/23912329 http://dx.doi.org/10.3390/nu5083022 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Castiglioni, Sara Cazzaniga, Alessandra Albisetti, Walter Maier, Jeanette A. M. Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions |
title | Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions |
title_full | Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions |
title_fullStr | Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions |
title_full_unstemmed | Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions |
title_short | Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions |
title_sort | magnesium and osteoporosis: current state of knowledge and future research directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775240/ https://www.ncbi.nlm.nih.gov/pubmed/23912329 http://dx.doi.org/10.3390/nu5083022 |
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