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Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions

A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone...

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Detalles Bibliográficos
Autores principales: Castiglioni, Sara, Cazzaniga, Alessandra, Albisetti, Walter, Maier, Jeanette A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775240/
https://www.ncbi.nlm.nih.gov/pubmed/23912329
http://dx.doi.org/10.3390/nu5083022
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author Castiglioni, Sara
Cazzaniga, Alessandra
Albisetti, Walter
Maier, Jeanette A. M.
author_facet Castiglioni, Sara
Cazzaniga, Alessandra
Albisetti, Walter
Maier, Jeanette A. M.
author_sort Castiglioni, Sara
collection PubMed
description A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity.
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spelling pubmed-37752402013-09-17 Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions Castiglioni, Sara Cazzaniga, Alessandra Albisetti, Walter Maier, Jeanette A. M. Nutrients Review A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity. MDPI 2013-07-31 /pmc/articles/PMC3775240/ /pubmed/23912329 http://dx.doi.org/10.3390/nu5083022 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Castiglioni, Sara
Cazzaniga, Alessandra
Albisetti, Walter
Maier, Jeanette A. M.
Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
title Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
title_full Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
title_fullStr Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
title_full_unstemmed Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
title_short Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
title_sort magnesium and osteoporosis: current state of knowledge and future research directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775240/
https://www.ncbi.nlm.nih.gov/pubmed/23912329
http://dx.doi.org/10.3390/nu5083022
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