Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications

The successful development of a mucosal vaccine depends critically on the use of a safe and effective immunostimulant and/or carrier system. This review describes the effectiveness and mode of action of an immunostimulating particle, derived from bacteria, used in mucosal subunit vaccines. The non-l...

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Autores principales: Van Braeckel-Budimir, Natalija, Haijema, Bert Jan, Leenhouts, Kees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775300/
https://www.ncbi.nlm.nih.gov/pubmed/24062748
http://dx.doi.org/10.3389/fimmu.2013.00282
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author Van Braeckel-Budimir, Natalija
Haijema, Bert Jan
Leenhouts, Kees
author_facet Van Braeckel-Budimir, Natalija
Haijema, Bert Jan
Leenhouts, Kees
author_sort Van Braeckel-Budimir, Natalija
collection PubMed
description The successful development of a mucosal vaccine depends critically on the use of a safe and effective immunostimulant and/or carrier system. This review describes the effectiveness and mode of action of an immunostimulating particle, derived from bacteria, used in mucosal subunit vaccines. The non-living particles, designated bacterium-like particles are based on the food-grade bacterium Lactococcus lactis. The focus of the overview is on the development of intranasal BLP-based vaccines to prevent diseases caused by influenza and respiratory syncytial virus, and includes a selection of Phase I clinical data for the intranasal FluGEM vaccine.
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spelling pubmed-37753002013-09-23 Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications Van Braeckel-Budimir, Natalija Haijema, Bert Jan Leenhouts, Kees Front Immunol Immunology The successful development of a mucosal vaccine depends critically on the use of a safe and effective immunostimulant and/or carrier system. This review describes the effectiveness and mode of action of an immunostimulating particle, derived from bacteria, used in mucosal subunit vaccines. The non-living particles, designated bacterium-like particles are based on the food-grade bacterium Lactococcus lactis. The focus of the overview is on the development of intranasal BLP-based vaccines to prevent diseases caused by influenza and respiratory syncytial virus, and includes a selection of Phase I clinical data for the intranasal FluGEM vaccine. Frontiers Media S.A. 2013-09-17 /pmc/articles/PMC3775300/ /pubmed/24062748 http://dx.doi.org/10.3389/fimmu.2013.00282 Text en Copyright © 2013 Van Braeckel-Budimir, Haijema and Leenhouts. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Van Braeckel-Budimir, Natalija
Haijema, Bert Jan
Leenhouts, Kees
Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications
title Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications
title_full Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications
title_fullStr Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications
title_full_unstemmed Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications
title_short Bacterium-Like Particles for Efficient Immune Stimulation of Existing Vaccines and New Subunit Vaccines in Mucosal Applications
title_sort bacterium-like particles for efficient immune stimulation of existing vaccines and new subunit vaccines in mucosal applications
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775300/
https://www.ncbi.nlm.nih.gov/pubmed/24062748
http://dx.doi.org/10.3389/fimmu.2013.00282
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