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Genomic Rearrangements of PTEN in Prostate Cancer

The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23.3 is a negative regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor suppressor gene in prostate cancer. Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss...

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Detalles Bibliográficos
Autores principales:	Phin, Sopheap, Moore, Mathew W., Cotter, Philip D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775430/ https://www.ncbi.nlm.nih.gov/pubmed/24062990 http://dx.doi.org/10.3389/fonc.2013.00240

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