Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon

[Image: see text] The major plant growth regulator ethephon degrades to ethylene and phosphate in aqueous solutions and plants and is spontaneously activated to a butyrylcholinesterase (BChE) inhibitor in alkaline solutions and animal tissues. In the present (31)P NMR kinetic study of the reactions...

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Autores principales: Lantz, Stephen R., Casida, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775443/
https://www.ncbi.nlm.nih.gov/pubmed/23927580
http://dx.doi.org/10.1021/tx4002429
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author Lantz, Stephen R.
Casida, John E.
author_facet Lantz, Stephen R.
Casida, John E.
author_sort Lantz, Stephen R.
collection PubMed
description [Image: see text] The major plant growth regulator ethephon degrades to ethylene and phosphate in aqueous solutions and plants and is spontaneously activated to a butyrylcholinesterase (BChE) inhibitor in alkaline solutions and animal tissues. In the present (31)P NMR kinetic study of the reactions of ethephon in pH 7.4 carbonate buffer, we observed a transient peak at 28.11 ppm. The time course for the appearance and disappearance of this peak matches the activation/degradation kinetic profile of the BChE inhibitor, and the chemical shift supports the proposed 2-oxo-2-hydroxy-1,2-oxaphosphetane structure.
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spelling pubmed-37754432013-09-18 Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon Lantz, Stephen R. Casida, John E. Chem Res Toxicol [Image: see text] The major plant growth regulator ethephon degrades to ethylene and phosphate in aqueous solutions and plants and is spontaneously activated to a butyrylcholinesterase (BChE) inhibitor in alkaline solutions and animal tissues. In the present (31)P NMR kinetic study of the reactions of ethephon in pH 7.4 carbonate buffer, we observed a transient peak at 28.11 ppm. The time course for the appearance and disappearance of this peak matches the activation/degradation kinetic profile of the BChE inhibitor, and the chemical shift supports the proposed 2-oxo-2-hydroxy-1,2-oxaphosphetane structure. American Chemical Society 2013-08-08 2013-09-16 /pmc/articles/PMC3775443/ /pubmed/23927580 http://dx.doi.org/10.1021/tx4002429 Text en Copyright © 2013 American Chemical Society Terms of Use CC-BY-NC-ND (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html)
spellingShingle Lantz, Stephen R.
Casida, John E.
Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon
title Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon
title_full Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon
title_fullStr Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon
title_full_unstemmed Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon
title_short Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon
title_sort characterization of the transient oxaphosphetane bche inhibitor formed from spontaneously activated ethephon
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775443/
https://www.ncbi.nlm.nih.gov/pubmed/23927580
http://dx.doi.org/10.1021/tx4002429
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