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The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging

The subventricular zone (SVZ) is the largest source of newly generated cells in the adult mammalian brain. SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into mature neurons. Additionally, a small proportion of SVZ-derived...

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Autores principales: Capilla-Gonzalez, Vivian, Cebrian-Silla, Arantxa, Guerrero-Cazares, Hugo, Garcia-Verdugo, Jose M., Quiñones-Hinojosa, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775451/
https://www.ncbi.nlm.nih.gov/pubmed/24062640
http://dx.doi.org/10.3389/fncel.2013.00147
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author Capilla-Gonzalez, Vivian
Cebrian-Silla, Arantxa
Guerrero-Cazares, Hugo
Garcia-Verdugo, Jose M.
Quiñones-Hinojosa, Alfredo
author_facet Capilla-Gonzalez, Vivian
Cebrian-Silla, Arantxa
Guerrero-Cazares, Hugo
Garcia-Verdugo, Jose M.
Quiñones-Hinojosa, Alfredo
author_sort Capilla-Gonzalez, Vivian
collection PubMed
description The subventricular zone (SVZ) is the largest source of newly generated cells in the adult mammalian brain. SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into mature neurons. Additionally, a small proportion of SVZ-derived cells contribute to the generation of myelinating oligodendrocytes. The production of new cells in the SVZ decreases during aging, affecting the incorporation of new neurons into the OB. However, the age-related changes that occur across the RMS are not fully understood. In this study we evaluate how aging affects the cellular organization of migrating neuroblast chains, the proliferation, and the fate of the newly generated cells in the SVZ-OB system. By using electron microscopy and immunostaining, we found that the RMS path becomes discontinuous and its cytoarchitecture is disorganized in aged mice (24-month-old mice). Subsequently, OB neurogenesis was impaired in the aged brain while the production of oligodendrocytes was not compromised. These findings provide new insight into oligodendrocyte preservation throughout life. Further exploration of this matter could help the development of new strategies to prevent neurological disorders associated with senescence.
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spelling pubmed-37754512013-09-23 The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging Capilla-Gonzalez, Vivian Cebrian-Silla, Arantxa Guerrero-Cazares, Hugo Garcia-Verdugo, Jose M. Quiñones-Hinojosa, Alfredo Front Cell Neurosci Neuroscience The subventricular zone (SVZ) is the largest source of newly generated cells in the adult mammalian brain. SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into mature neurons. Additionally, a small proportion of SVZ-derived cells contribute to the generation of myelinating oligodendrocytes. The production of new cells in the SVZ decreases during aging, affecting the incorporation of new neurons into the OB. However, the age-related changes that occur across the RMS are not fully understood. In this study we evaluate how aging affects the cellular organization of migrating neuroblast chains, the proliferation, and the fate of the newly generated cells in the SVZ-OB system. By using electron microscopy and immunostaining, we found that the RMS path becomes discontinuous and its cytoarchitecture is disorganized in aged mice (24-month-old mice). Subsequently, OB neurogenesis was impaired in the aged brain while the production of oligodendrocytes was not compromised. These findings provide new insight into oligodendrocyte preservation throughout life. Further exploration of this matter could help the development of new strategies to prevent neurological disorders associated with senescence. Frontiers Media S.A. 2013-09-11 /pmc/articles/PMC3775451/ /pubmed/24062640 http://dx.doi.org/10.3389/fncel.2013.00147 Text en Copyright © 2013 Capilla-Gonzalez, Cebrian-Silla, Guerrero-Cazares, Garcia-Verdugo and Quinones-Hinojosa. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Capilla-Gonzalez, Vivian
Cebrian-Silla, Arantxa
Guerrero-Cazares, Hugo
Garcia-Verdugo, Jose M.
Quiñones-Hinojosa, Alfredo
The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
title The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
title_full The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
title_fullStr The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
title_full_unstemmed The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
title_short The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
title_sort generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775451/
https://www.ncbi.nlm.nih.gov/pubmed/24062640
http://dx.doi.org/10.3389/fncel.2013.00147
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