Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions

Affinity maturation occurs through two selection processes: the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed...

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Detalles Bibliográficos
Autores principales: Liberman, Gilad, Benichou, Jennifer, Tsaban, Lea, Glanville, Jacob, Louzoun, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775539/
https://www.ncbi.nlm.nih.gov/pubmed/24062742
http://dx.doi.org/10.3389/fimmu.2013.00274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775539/
https://www.ncbi.nlm.nih.gov/pubmed/24062742
http://dx.doi.org/10.3389/fimmu.2013.00274

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