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Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions
Affinity maturation occurs through two selection processes: the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775539/ https://www.ncbi.nlm.nih.gov/pubmed/24062742 http://dx.doi.org/10.3389/fimmu.2013.00274 |