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Genetic differences between Asian and Caucasian chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a common hematological malignancy in Western countries. However, this disease is very rare in Asian countries. It is not clear whether the mechanisms of development of CLL in Caucasians and Asians are the same. We compared genetic abnormalities in Asian and Cauc...

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Autores principales: KAWAMATA, NORIHIKO, MOREILHON, CHIMENE, SAITOH, TAKAYUKI, KARASAWA, MASAMITSU, BERNSTEIN, BRIAN K., SATO-OTSUBO, AIKO, OGAWA, SEISHI, RAYNAUD, SOPHIE, KOEFFLER, H. PHILLIP
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775563/
https://www.ncbi.nlm.nih.gov/pubmed/23708256
http://dx.doi.org/10.3892/ijo.2013.1966
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author KAWAMATA, NORIHIKO
MOREILHON, CHIMENE
SAITOH, TAKAYUKI
KARASAWA, MASAMITSU
BERNSTEIN, BRIAN K.
SATO-OTSUBO, AIKO
OGAWA, SEISHI
RAYNAUD, SOPHIE
KOEFFLER, H. PHILLIP
author_facet KAWAMATA, NORIHIKO
MOREILHON, CHIMENE
SAITOH, TAKAYUKI
KARASAWA, MASAMITSU
BERNSTEIN, BRIAN K.
SATO-OTSUBO, AIKO
OGAWA, SEISHI
RAYNAUD, SOPHIE
KOEFFLER, H. PHILLIP
author_sort KAWAMATA, NORIHIKO
collection PubMed
description Chronic lymphocytic leukemia (CLL) is a common hematological malignancy in Western countries. However, this disease is very rare in Asian countries. It is not clear whether the mechanisms of development of CLL in Caucasians and Asians are the same. We compared genetic abnormalities in Asian and Caucasian CLL using 250k GeneChip arrays. Both Asian and Caucasian CLL had four common genetic abnormalities: deletion of 13q14.3, trisomy 12, abnormalities of ATM (11q) and abnormalities of 17p. Interestingly, trisomy 12 and deletion of 13q14.3 were mutually exclusive in both groups. We also found that deletions of miR 34b/34c (11q), caspase 1/4/5 (11q), Rb1 (13q) and DLC1 (8p) are common in both ethnic groups. Asian CLL more frequently had gain of 3q and 18q. These suggest that classic genomic changes in the Asian and Caucasina CLL are same. Further, we found amplification of IRF4 and deletion of the SP140/SP100 genes; these genes have been reported as CLL-associated genes by previous genome-wide-association study. We have found classic genomic abnormalities in Asian CLL as well as novel genomic alteration in CLL.
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spelling pubmed-37755632013-09-18 Genetic differences between Asian and Caucasian chronic lymphocytic leukemia KAWAMATA, NORIHIKO MOREILHON, CHIMENE SAITOH, TAKAYUKI KARASAWA, MASAMITSU BERNSTEIN, BRIAN K. SATO-OTSUBO, AIKO OGAWA, SEISHI RAYNAUD, SOPHIE KOEFFLER, H. PHILLIP Int J Oncol Articles Chronic lymphocytic leukemia (CLL) is a common hematological malignancy in Western countries. However, this disease is very rare in Asian countries. It is not clear whether the mechanisms of development of CLL in Caucasians and Asians are the same. We compared genetic abnormalities in Asian and Caucasian CLL using 250k GeneChip arrays. Both Asian and Caucasian CLL had four common genetic abnormalities: deletion of 13q14.3, trisomy 12, abnormalities of ATM (11q) and abnormalities of 17p. Interestingly, trisomy 12 and deletion of 13q14.3 were mutually exclusive in both groups. We also found that deletions of miR 34b/34c (11q), caspase 1/4/5 (11q), Rb1 (13q) and DLC1 (8p) are common in both ethnic groups. Asian CLL more frequently had gain of 3q and 18q. These suggest that classic genomic changes in the Asian and Caucasina CLL are same. Further, we found amplification of IRF4 and deletion of the SP140/SP100 genes; these genes have been reported as CLL-associated genes by previous genome-wide-association study. We have found classic genomic abnormalities in Asian CLL as well as novel genomic alteration in CLL. D.A. Spandidos 2013-05-27 /pmc/articles/PMC3775563/ /pubmed/23708256 http://dx.doi.org/10.3892/ijo.2013.1966 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
KAWAMATA, NORIHIKO
MOREILHON, CHIMENE
SAITOH, TAKAYUKI
KARASAWA, MASAMITSU
BERNSTEIN, BRIAN K.
SATO-OTSUBO, AIKO
OGAWA, SEISHI
RAYNAUD, SOPHIE
KOEFFLER, H. PHILLIP
Genetic differences between Asian and Caucasian chronic lymphocytic leukemia
title Genetic differences between Asian and Caucasian chronic lymphocytic leukemia
title_full Genetic differences between Asian and Caucasian chronic lymphocytic leukemia
title_fullStr Genetic differences between Asian and Caucasian chronic lymphocytic leukemia
title_full_unstemmed Genetic differences between Asian and Caucasian chronic lymphocytic leukemia
title_short Genetic differences between Asian and Caucasian chronic lymphocytic leukemia
title_sort genetic differences between asian and caucasian chronic lymphocytic leukemia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775563/
https://www.ncbi.nlm.nih.gov/pubmed/23708256
http://dx.doi.org/10.3892/ijo.2013.1966
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