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Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells

Murine dendritic cells (DC) transduced to express the Type-1 transactivator T-bet (i.e. mDC.Tbet) and delivered intratumorally (i.t.) as a therapy are superior to control wild-type DC in slowing the growth of established subcutaneous (s.c.) MCA205 sarcomas in vivo. Optimal anti-tumor efficacy of mDC...

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Detalles Bibliográficos
Autores principales:	Chen, Lu, Taylor, Jennifer L., Sabins, Nina Chi, Lowe, Devin B., Qu, Yanyan, You, Zhaoyang, Storkus, Walter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775601/ https://www.ncbi.nlm.nih.gov/pubmed/23846252 http://dx.doi.org/10.1038/cgt.2013.42

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