Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice

The pathogenesis of focal segmental glomerulosclerosis (FSGS) is considered to be associated with oxidative stress, mononuclear leukocyte recruitment and infiltration, and matrix production and/or matrix degradation, although the exact etiology and pathogenic pathways remain to be determined. Establ...

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Autores principales: Yang, Shun-Min, Hua, Kuo-Feng, Lin, Yu-Chuan, Chen, Ann, Chang, Jia-Ming, Kuoping Chao, Louis, Ho, Chen-Lung, Ka, Shuk-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775727/
https://www.ncbi.nlm.nih.gov/pubmed/24069362
http://dx.doi.org/10.1371/journal.pone.0074871
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author Yang, Shun-Min
Hua, Kuo-Feng
Lin, Yu-Chuan
Chen, Ann
Chang, Jia-Ming
Kuoping Chao, Louis
Ho, Chen-Lung
Ka, Shuk-Man
author_facet Yang, Shun-Min
Hua, Kuo-Feng
Lin, Yu-Chuan
Chen, Ann
Chang, Jia-Ming
Kuoping Chao, Louis
Ho, Chen-Lung
Ka, Shuk-Man
author_sort Yang, Shun-Min
collection PubMed
description The pathogenesis of focal segmental glomerulosclerosis (FSGS) is considered to be associated with oxidative stress, mononuclear leukocyte recruitment and infiltration, and matrix production and/or matrix degradation, although the exact etiology and pathogenic pathways remain to be determined. Establishment of a pathogenesis-based therapeutic strategy for the disease is clinically warranted. Citral (3,7-dimethyl-2,6-octadienal), a major active compound in Litsea cubeba , a traditional Chinese herbal medicine, can inhibit oxidant activity, macrophage and NF-κB activation. In the present study, first, we used a mouse model of FSGS with the features of glomerular epithelial hyperplasia lesions (EPHLs), a key histopathology index of progression of FSGS, peri-glomerular inflammation, and progressive glomerular hyalinosis/sclerosis. When treated with citral for 28 consecutive days at a daily dose of 200 mg/kg of body weight by gavage, the FSGS mice showed greatly reduced EPHLs, glomerular hyalinosis/sclerosis and peri-glomerular mononuclear leukocyte infiltration, suggesting that citral may be renoprotective for FSGS and act by inhibiting oxidative stress and apoptosis and early activating the Nrf2 pathway. Meanwhile, a macrophage model involved in anti-oxidative and anti-inflammatory activities was employed and confirmed the beneficial effects of citral on the FSGS model.
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spelling pubmed-37757272013-09-25 Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice Yang, Shun-Min Hua, Kuo-Feng Lin, Yu-Chuan Chen, Ann Chang, Jia-Ming Kuoping Chao, Louis Ho, Chen-Lung Ka, Shuk-Man PLoS One Research Article The pathogenesis of focal segmental glomerulosclerosis (FSGS) is considered to be associated with oxidative stress, mononuclear leukocyte recruitment and infiltration, and matrix production and/or matrix degradation, although the exact etiology and pathogenic pathways remain to be determined. Establishment of a pathogenesis-based therapeutic strategy for the disease is clinically warranted. Citral (3,7-dimethyl-2,6-octadienal), a major active compound in Litsea cubeba , a traditional Chinese herbal medicine, can inhibit oxidant activity, macrophage and NF-κB activation. In the present study, first, we used a mouse model of FSGS with the features of glomerular epithelial hyperplasia lesions (EPHLs), a key histopathology index of progression of FSGS, peri-glomerular inflammation, and progressive glomerular hyalinosis/sclerosis. When treated with citral for 28 consecutive days at a daily dose of 200 mg/kg of body weight by gavage, the FSGS mice showed greatly reduced EPHLs, glomerular hyalinosis/sclerosis and peri-glomerular mononuclear leukocyte infiltration, suggesting that citral may be renoprotective for FSGS and act by inhibiting oxidative stress and apoptosis and early activating the Nrf2 pathway. Meanwhile, a macrophage model involved in anti-oxidative and anti-inflammatory activities was employed and confirmed the beneficial effects of citral on the FSGS model. Public Library of Science 2013-09-17 /pmc/articles/PMC3775727/ /pubmed/24069362 http://dx.doi.org/10.1371/journal.pone.0074871 Text en © 2013 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Shun-Min
Hua, Kuo-Feng
Lin, Yu-Chuan
Chen, Ann
Chang, Jia-Ming
Kuoping Chao, Louis
Ho, Chen-Lung
Ka, Shuk-Man
Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice
title Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice
title_full Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice
title_fullStr Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice
title_full_unstemmed Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice
title_short Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice
title_sort citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating nrf2 pathway in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775727/
https://www.ncbi.nlm.nih.gov/pubmed/24069362
http://dx.doi.org/10.1371/journal.pone.0074871
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