A Randomised, Placebo-Controlled, First-In-Human Study of a Novel Clade C Therapeutic Peptide Vaccine Administered Ex Vivo to Autologous White Blood Cells in HIV Infected Individuals

BACKGROUND: Preclinical studies of overlapping 15mer peptides, spanning SIV, SHIV or HIV, pulsed on autologous PBMC ex vivo have demonstrated high level, virus-specific T cell responses and viral suppression in non-human primates (NHP). Opal-HIV-Gag(c) consists of 120 synthetic 15mer peptides spanni...

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Detalles Bibliográficos
Autores principales: Jackson, Akil, Kløverpris, Henrik N., Boffito, Marta, Handley, Amanda, Atkins, Mark, Hayes, Peter, Gilmour, Jill, Riddel, Lynn, Chen, Fabian, Bailey-Tippets, Melanie, Walker, Bruce, Ackland, Jim, Sullivan, Mark, Goulder, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775760/
https://www.ncbi.nlm.nih.gov/pubmed/24069230
http://dx.doi.org/10.1371/journal.pone.0073765

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