Ginkgolide B Reduces LOX-1 Expression by Inhibiting Akt Phosphorylation and Increasing Sirt1 Expression in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells

Oxidized low-density lipoprotein (ox-LDL) is an important risk factor in the development of atherosclerosis. LOX-1, a lectin-like receptor for ox-LDL, is present primarily on endothelial cells and upregulated by ox-LDL, tumor necrosis factor a, shear stress, and cytokines in atherosclerosis. Recent...

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Detalles Bibliográficos
Autores principales: Ma, Lina, Liu, Xueqing, Zhao, Yanyang, Chen, Beidong, Li, Xingguang, Qi, Ruomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775799/
https://www.ncbi.nlm.nih.gov/pubmed/24069345
http://dx.doi.org/10.1371/journal.pone.0074769

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