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Riccardin D Exerts Its Antitumor Activity by Inducing DNA Damage in PC-3 Prostate Cancer Cells In Vitro and In Vivo

We recently reported that Riccardin D (RD) was able to induce apoptosis by targeting Topo II. Here, we found that RD induced cell cycle arrest in G2/M phase in PC-3 cells, and caused remarkable DNA damage as evidenced by induction of γH2AX foci, micronuclei, and DNA fragmentation in Comet assay. Tim...

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Detalles Bibliográficos
Autores principales:	Hu, Zhongyi, Kong, Feng, Si, Manfei, Tian, Keli, Yu, Lin Xi, Young, Charles Y. F., Yuan, Huiqing, Lou, Hongxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775815/ https://www.ncbi.nlm.nih.gov/pubmed/24069304 http://dx.doi.org/10.1371/journal.pone.0074387

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