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Function and expression of prolyl hydroxylase 3 in cancers

Hypoxia inducible factor (HIF) is a product of tumor cells that plays an important role in protecting tumor cells and adjusting to low oxygen tension through driving the progression and aggressiveness of tumors and changing the growth, angiogenesis, differentiation and metastasis of tumors. Prolyl h...

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Autores principales: Liu, Qiu-long, Liang, Qi-lian, Li, Zhou-yu, Zhou, Yuan, Ou, Wen-Ting, Huang, Zhi-gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776186/
https://www.ncbi.nlm.nih.gov/pubmed/24049515
http://dx.doi.org/10.5114/aoms.2013.36987
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author Liu, Qiu-long
Liang, Qi-lian
Li, Zhou-yu
Zhou, Yuan
Ou, Wen-Ting
Huang, Zhi-gang
author_facet Liu, Qiu-long
Liang, Qi-lian
Li, Zhou-yu
Zhou, Yuan
Ou, Wen-Ting
Huang, Zhi-gang
author_sort Liu, Qiu-long
collection PubMed
description Hypoxia inducible factor (HIF) is a product of tumor cells that plays an important role in protecting tumor cells and adjusting to low oxygen tension through driving the progression and aggressiveness of tumors and changing the growth, angiogenesis, differentiation and metastasis of tumors. Prolyl hydroxylase 3 (PHD3) is a member of PHDs that are induced in hypoxia. Many studies have shown that PHD3 not only can hydroxylate HIF-1α, but also has various other biological functions. Thus PHD3 plays significant roles in suppressing the growth, angiogenesis, differentiation and metastasis of tumors and promoting apoptosis of tumors under hypoxic conditions. It may become a new tumor suppressor gene and also may become a new approach to investigate tumors.
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spelling pubmed-37761862013-09-18 Function and expression of prolyl hydroxylase 3 in cancers Liu, Qiu-long Liang, Qi-lian Li, Zhou-yu Zhou, Yuan Ou, Wen-Ting Huang, Zhi-gang Arch Med Sci State of the Art Paper Hypoxia inducible factor (HIF) is a product of tumor cells that plays an important role in protecting tumor cells and adjusting to low oxygen tension through driving the progression and aggressiveness of tumors and changing the growth, angiogenesis, differentiation and metastasis of tumors. Prolyl hydroxylase 3 (PHD3) is a member of PHDs that are induced in hypoxia. Many studies have shown that PHD3 not only can hydroxylate HIF-1α, but also has various other biological functions. Thus PHD3 plays significant roles in suppressing the growth, angiogenesis, differentiation and metastasis of tumors and promoting apoptosis of tumors under hypoxic conditions. It may become a new tumor suppressor gene and also may become a new approach to investigate tumors. Termedia Publishing House 2013-08-29 2013-08-30 /pmc/articles/PMC3776186/ /pubmed/24049515 http://dx.doi.org/10.5114/aoms.2013.36987 Text en Copyright © 2013 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle State of the Art Paper
Liu, Qiu-long
Liang, Qi-lian
Li, Zhou-yu
Zhou, Yuan
Ou, Wen-Ting
Huang, Zhi-gang
Function and expression of prolyl hydroxylase 3 in cancers
title Function and expression of prolyl hydroxylase 3 in cancers
title_full Function and expression of prolyl hydroxylase 3 in cancers
title_fullStr Function and expression of prolyl hydroxylase 3 in cancers
title_full_unstemmed Function and expression of prolyl hydroxylase 3 in cancers
title_short Function and expression of prolyl hydroxylase 3 in cancers
title_sort function and expression of prolyl hydroxylase 3 in cancers
topic State of the Art Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776186/
https://www.ncbi.nlm.nih.gov/pubmed/24049515
http://dx.doi.org/10.5114/aoms.2013.36987
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