Cellular and molecular mechanisms underlying axon formation, growth, and branching

Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and functionally, and this polarization requires the segregation of mRNA, proteins, and lipids into the axonal or somatodendritic domains. Recent discoveries...

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Detalles Bibliográficos
Autores principales: Lewis, Tommy L., Courchet, Julien, Polleux, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776347/
https://www.ncbi.nlm.nih.gov/pubmed/24043699
http://dx.doi.org/10.1083/jcb.201305098
Descripción
Sumario:Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and functionally, and this polarization requires the segregation of mRNA, proteins, and lipids into the axonal or somatodendritic domains. Recent discoveries have provided insight into many aspects of the cell biology of axonal development including axon specification during neuronal polarization, axon growth, and terminal axon branching during synaptogenesis.

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