aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian aPKCs control stem cells and fate in vivo is not known. Here we show that loss of aPKCλ in a self-renewing epithelium, the epidermis, disturbed tissue homeostasis, differe...

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Detalles Bibliográficos
Autores principales: Niessen, Michaela T., Scott, Jeanie, Zielinski, Julia G., Vorhagen, Susanne, Sotiropoulou, Panagiota A., Blanpain, Cédric, Leitges, Michael, Niessen, Carien M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776350/
https://www.ncbi.nlm.nih.gov/pubmed/24019538
http://dx.doi.org/10.1083/jcb.201307001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776350/
https://www.ncbi.nlm.nih.gov/pubmed/24019538
http://dx.doi.org/10.1083/jcb.201307001

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