Influence of the SCN1A IVS5N + 5 G>A Polymorphism on Therapy with Carbamazepine for Epilepsy

Carbamazepine (CBZ) blocks neuronal sodium channels in a voltage- and frequency-dependent manner, delaying the recovery of the channels from the inactivated state, reducing the number of action potentials within a burst, and decreasing burst duration. The α-subunit of the first neuronal sodium chann...

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Detalles Bibliográficos
Autores principales: Sterjev, Z, Kiteva, G, Cvetkovska, E, Petrov, I, Kuzmanovski, I, Ribarska, TJ, Nestorovska, KA, Matevska, N, Trajkovik-Jolevska, S, Dimovski, AJ, Suturkova, Lj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Macedonian Science of Sciences and Arts 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776651/
https://www.ncbi.nlm.nih.gov/pubmed/24052718
http://dx.doi.org/10.2478/v10034-012-0003-1

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