Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites

This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European male-bias...

Descripción completa

Detalles Bibliográficos
Autores principales: Battaggia, C, Anagnostou, P, Bosch, I, Brisighelli, F, Destro-Bisol, G, Capocasa, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Macedonian Science of Sciences and Arts 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776662/
https://www.ncbi.nlm.nih.gov/pubmed/24052726
http://dx.doi.org/10.2478/bjmg-2013-0001
_version_ 1782477501845471232
author Battaggia, C
Anagnostou, P
Bosch, I
Brisighelli, F
Destro-Bisol, G
Capocasa, M
author_facet Battaggia, C
Anagnostou, P
Bosch, I
Brisighelli, F
Destro-Bisol, G
Capocasa, M
author_sort Battaggia, C
collection PubMed
description This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European male-biased gene flow. We show that comparisons of intra-and inter-population diversity parameters between African-Americans, Europeans and Africans may help detect sex-biased gene flow, providing a complement to quantitative methods to estimate genetic admixture.
format Online
Article
Text
id pubmed-3776662
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Macedonian Science of Sciences and Arts
record_format MEDLINE/PubMed
spelling pubmed-37766622013-09-19 Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites Battaggia, C Anagnostou, P Bosch, I Brisighelli, F Destro-Bisol, G Capocasa, M Balkan J Med Genet Original Article This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European male-biased gene flow. We show that comparisons of intra-and inter-population diversity parameters between African-Americans, Europeans and Africans may help detect sex-biased gene flow, providing a complement to quantitative methods to estimate genetic admixture. Macedonian Science of Sciences and Arts 2012-12 2013-04-02 /pmc/articles/PMC3776662/ /pubmed/24052726 http://dx.doi.org/10.2478/bjmg-2013-0001 Text en © Macedonian Academy of Sciences and Arts This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs license (http://creativecommons.org/licenses/by-nc-nd/3.0/), which means that the text may be used for non-commercial purposes, provided credit is given to the author.
spellingShingle Original Article
Battaggia, C
Anagnostou, P
Bosch, I
Brisighelli, F
Destro-Bisol, G
Capocasa, M
Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites
title Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites
title_full Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites
title_fullStr Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites
title_full_unstemmed Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites
title_short Detecting Sex-Biased Gene Flow in African-Americans through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites
title_sort detecting sex-biased gene flow in african-americans through the analysis of intra- and inter-population variation at mitochondrial dna and y- chromosome microsatellites
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776662/
https://www.ncbi.nlm.nih.gov/pubmed/24052726
http://dx.doi.org/10.2478/bjmg-2013-0001
work_keys_str_mv AT battaggiac detectingsexbiasedgeneflowinafricanamericansthroughtheanalysisofintraandinterpopulationvariationatmitochondrialdnaandychromosomemicrosatellites
AT anagnostoup detectingsexbiasedgeneflowinafricanamericansthroughtheanalysisofintraandinterpopulationvariationatmitochondrialdnaandychromosomemicrosatellites
AT boschi detectingsexbiasedgeneflowinafricanamericansthroughtheanalysisofintraandinterpopulationvariationatmitochondrialdnaandychromosomemicrosatellites
AT brisighellif detectingsexbiasedgeneflowinafricanamericansthroughtheanalysisofintraandinterpopulationvariationatmitochondrialdnaandychromosomemicrosatellites
AT destrobisolg detectingsexbiasedgeneflowinafricanamericansthroughtheanalysisofintraandinterpopulationvariationatmitochondrialdnaandychromosomemicrosatellites
AT capocasam detectingsexbiasedgeneflowinafricanamericansthroughtheanalysisofintraandinterpopulationvariationatmitochondrialdnaandychromosomemicrosatellites

Ejemplares similares