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The Impact of Ovariectomy on Calcium Homeostasis and Myofilament Calcium Sensitivity in the Aging Mouse Heart

This study determined whether deficiency of ovarian estrogen starting very early in life promoted age-associated Ca(2+) dysregulation and contractile dysfunction in isolated ventricular myocytes. Myocytes were isolated from anesthetized C57BL/6 female mice. Animals received an ovariectomy or sham-op...

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Detalles Bibliográficos
Autores principales:	Fares, Elias, Pyle, W. Glen, Ray, Gibanananda, Rose, Robert A., Denovan-Wright, Eileen M., Chen, Robert P., Howlett, Susan E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776741/ https://www.ncbi.nlm.nih.gov/pubmed/24058623 http://dx.doi.org/10.1371/journal.pone.0074719

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