Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss

Stiff person syndrome (SPS) is a highly-disabling neurological disorder of the CNS characterized by progressive muscular rigidity and spasms. In approximately 60–80% of patients there are autoantibodies to glutamic acid decarboxylase (GAD), the enzyme that synthesizes gamma-amino butyric acid (GABA)...

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Detalles Bibliográficos
Autores principales: Chang, Thashi, Alexopoulos, Harry, Pettingill, Philippa, McMenamin, Mary, Deacon, Robert, Erdelyi, Ferenc, Szabó, Gabor, Buckley, Camilla J., Vincent, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776810/
https://www.ncbi.nlm.nih.gov/pubmed/24058450
http://dx.doi.org/10.1371/journal.pone.0072921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776810/
https://www.ncbi.nlm.nih.gov/pubmed/24058450
http://dx.doi.org/10.1371/journal.pone.0072921

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