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Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study

BACKGROUND: Mutations in the gene coding for glucocerebrosidase (GBA), which metabolizes glucosylceramide (a monohexosylceramide) into glucose and ceramide, is the most common genetic risk factor for sporadic Parkinson's disease (PD). GBA mutation carriers are more likely to have an earlier age...

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Detalles Bibliográficos
Autores principales:	Mielke, Michelle M., Maetzler, Walter, Haughey, Norman J., Bandaru, Veera V. R., Savica, Rodolfo, Deuschle, Christian, Gasser, Thomas, Hauser, Ann-Kathrin, Gräber-Sultan, Susanne, Schleicher, Erwin, Berg, Daniela, Liepelt-Scarfone, Inga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776817/ https://www.ncbi.nlm.nih.gov/pubmed/24058461 http://dx.doi.org/10.1371/journal.pone.0073094

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