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Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response()
The Rv0805 gene in Mycobacterium tuberculosis encodes a metallophosphoesterase which shows cAMP-hydrolytic activity. Overexpression of Rv0805 has been used as a tool to lower intracellular cAMP levels and thereby elucidate the roles of cAMP in mycobacteria. Here we show that levels of cAMP in M. tub...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Churchill Livingstone
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776917/ https://www.ncbi.nlm.nih.gov/pubmed/23835087 http://dx.doi.org/10.1016/j.tube.2013.05.004 |