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Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent form of dementia. The amyloid beta (Aβ) peptide is the predominant candidate aetiological agent and is generated through the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by beta (β) and gamma (γ) secretases. Since the cell...

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Detalles Bibliográficos
Autores principales:	Jovanovic, Katarina, Gonsalves, Danielle, Da Costa Dias, Bianca, Moodley, Kiashanee, Reusch, Uwe, Knackmuss, Stefan, Penny, Clement, Weinberg, Marc S., Little, Melvyn, Weiss, Stefan F. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776966/ https://www.ncbi.nlm.nih.gov/pubmed/24048412 http://dx.doi.org/10.1038/srep02699

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