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The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin

The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from yeast to humans, and have preserved their general architecture throughout evolution. They are composed of SUN and KASH domai...

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Detalles Bibliográficos
Autores principales: Rothballer, Andrea, Kutay, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777164/
https://www.ncbi.nlm.nih.gov/pubmed/23736899
http://dx.doi.org/10.1007/s00412-013-0417-x
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author Rothballer, Andrea
Kutay, Ulrike
author_facet Rothballer, Andrea
Kutay, Ulrike
author_sort Rothballer, Andrea
collection PubMed
description The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from yeast to humans, and have preserved their general architecture throughout evolution. They are composed of SUN and KASH domain proteins of the inner and the outer nuclear membrane, respectively. These SUN–KASH bridges are used for the transmission of forces across the NE and support diverse biological processes. Here, we review the function of SUN and KASH domain proteins in various unicellular and multicellular species. Specifically, we discuss their influence on nuclear morphology and cytoskeletal organization. Further, emphasis is given on the role of LINC complexes in nuclear anchorage and migration as well as in genome organization.
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spelling pubmed-37771642013-09-25 The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin Rothballer, Andrea Kutay, Ulrike Chromosoma Review The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from yeast to humans, and have preserved their general architecture throughout evolution. They are composed of SUN and KASH domain proteins of the inner and the outer nuclear membrane, respectively. These SUN–KASH bridges are used for the transmission of forces across the NE and support diverse biological processes. Here, we review the function of SUN and KASH domain proteins in various unicellular and multicellular species. Specifically, we discuss their influence on nuclear morphology and cytoskeletal organization. Further, emphasis is given on the role of LINC complexes in nuclear anchorage and migration as well as in genome organization. Springer Berlin Heidelberg 2013-06-05 2013 /pmc/articles/PMC3777164/ /pubmed/23736899 http://dx.doi.org/10.1007/s00412-013-0417-x Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Rothballer, Andrea
Kutay, Ulrike
The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
title The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
title_full The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
title_fullStr The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
title_full_unstemmed The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
title_short The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
title_sort diverse functional lincs of the nuclear envelope to the cytoskeleton and chromatin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777164/
https://www.ncbi.nlm.nih.gov/pubmed/23736899
http://dx.doi.org/10.1007/s00412-013-0417-x
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