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The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from yeast to humans, and have preserved their general architecture throughout evolution. They are composed of SUN and KASH domai...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777164/ https://www.ncbi.nlm.nih.gov/pubmed/23736899 http://dx.doi.org/10.1007/s00412-013-0417-x |
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author | Rothballer, Andrea Kutay, Ulrike |
author_facet | Rothballer, Andrea Kutay, Ulrike |
author_sort | Rothballer, Andrea |
collection | PubMed |
description | The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from yeast to humans, and have preserved their general architecture throughout evolution. They are composed of SUN and KASH domain proteins of the inner and the outer nuclear membrane, respectively. These SUN–KASH bridges are used for the transmission of forces across the NE and support diverse biological processes. Here, we review the function of SUN and KASH domain proteins in various unicellular and multicellular species. Specifically, we discuss their influence on nuclear morphology and cytoskeletal organization. Further, emphasis is given on the role of LINC complexes in nuclear anchorage and migration as well as in genome organization. |
format | Online Article Text |
id | pubmed-3777164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-37771642013-09-25 The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin Rothballer, Andrea Kutay, Ulrike Chromosoma Review The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from yeast to humans, and have preserved their general architecture throughout evolution. They are composed of SUN and KASH domain proteins of the inner and the outer nuclear membrane, respectively. These SUN–KASH bridges are used for the transmission of forces across the NE and support diverse biological processes. Here, we review the function of SUN and KASH domain proteins in various unicellular and multicellular species. Specifically, we discuss their influence on nuclear morphology and cytoskeletal organization. Further, emphasis is given on the role of LINC complexes in nuclear anchorage and migration as well as in genome organization. Springer Berlin Heidelberg 2013-06-05 2013 /pmc/articles/PMC3777164/ /pubmed/23736899 http://dx.doi.org/10.1007/s00412-013-0417-x Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Rothballer, Andrea Kutay, Ulrike The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin |
title | The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin |
title_full | The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin |
title_fullStr | The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin |
title_full_unstemmed | The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin |
title_short | The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin |
title_sort | diverse functional lincs of the nuclear envelope to the cytoskeleton and chromatin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777164/ https://www.ncbi.nlm.nih.gov/pubmed/23736899 http://dx.doi.org/10.1007/s00412-013-0417-x |
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