Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography–mass spectrometry and ion mobility mass spectrometry

Diosmin is a flavonoid often administered in the treatment of chronic venous insufficiency, hemorrhoids, and related affections. Diosmin is rapidly hydrolized in the intestine to its aglicone, diosmetin, which is further metabolized to conjugates. In this study, the development and validations of th...

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Detalles Bibliográficos
Autores principales: Silvestro, Luigi, Tarcomnicu, Isabela, Dulea, Constanta, Attili, Nageswara Rao B. N., Ciuca, Valentin, Peru, Dan, Rizea Savu, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777223/
https://www.ncbi.nlm.nih.gov/pubmed/23949323
http://dx.doi.org/10.1007/s00216-013-7237-y

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