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A study of neuropsychiatric manifestations in patients of neurocysticercosis

BACKGROUND: Neurocysticercosis (NCC) is an endemic parasitic infection of Asia, Africa, Latin America, and central Europe. Neuropsychiatric manifestations of the illness include epilepsy and behavioral disturbances. There is a dearth of systematic studies on psychiatric manifestations of NCC from va...

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Autores principales: Srivastava, Smita, Chadda, Rakesh Kumar, Bala, Kiran, Majumdar, Pradipta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777348/
https://www.ncbi.nlm.nih.gov/pubmed/24082247
http://dx.doi.org/10.4103/0019-5545.117146
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author Srivastava, Smita
Chadda, Rakesh Kumar
Bala, Kiran
Majumdar, Pradipta
author_facet Srivastava, Smita
Chadda, Rakesh Kumar
Bala, Kiran
Majumdar, Pradipta
author_sort Srivastava, Smita
collection PubMed
description BACKGROUND: Neurocysticercosis (NCC) is an endemic parasitic infection of Asia, Africa, Latin America, and central Europe. Neuropsychiatric manifestations of the illness include epilepsy and behavioral disturbances. There is a dearth of systematic studies on psychiatric manifestations of NCC from various Asian counties. The present study assessed the prevalence of various psychiatric disorders in a cohort of patients with NCC attending a neurological service. MATERIALS AND METHODS: Detailed psychiatric assessment was carried out on 50 patients of NCC with epilepsy and 50 patients of epilepsy without any evidence of NCC. Comprehensive Psychopathological Rating Scale was used to elicit the symptoms. Cognitive functions were assessed using Mini Mental Status Examination. Psychiatric diagnoses were made as per International Classification of Diseases, 10(th) edition (ICD-10). RESULTS: Sixty eight percent of the patients with NCC suffered from a psychiatric disorder, as compared to 44% of those without NCC (P=0.02). Major depression and mixed anxiety depression were the two most common diagnoses. None of the patients was to found to suffer from a psychotic disorder. The most frequent site of brain lesion of NCC was the parietal lobe, followed by frontal lobes and disseminated lesions. Left sided lesions were associated with greater psychiatric morbidity. Focal seizures with or without secondary generalizations were present more frequently in patients with NCC whereas primary generalized seizures were more common in patients with idiopathic epilepsy (P=0.05). CONCLUSION: Psychiatric manifestations are more common in patients of epilepsy with NCC than those without NCC. The treating clinician need to be vigilant about the phenomenon.
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spelling pubmed-37773482013-09-30 A study of neuropsychiatric manifestations in patients of neurocysticercosis Srivastava, Smita Chadda, Rakesh Kumar Bala, Kiran Majumdar, Pradipta Indian J Psychiatry Original Article BACKGROUND: Neurocysticercosis (NCC) is an endemic parasitic infection of Asia, Africa, Latin America, and central Europe. Neuropsychiatric manifestations of the illness include epilepsy and behavioral disturbances. There is a dearth of systematic studies on psychiatric manifestations of NCC from various Asian counties. The present study assessed the prevalence of various psychiatric disorders in a cohort of patients with NCC attending a neurological service. MATERIALS AND METHODS: Detailed psychiatric assessment was carried out on 50 patients of NCC with epilepsy and 50 patients of epilepsy without any evidence of NCC. Comprehensive Psychopathological Rating Scale was used to elicit the symptoms. Cognitive functions were assessed using Mini Mental Status Examination. Psychiatric diagnoses were made as per International Classification of Diseases, 10(th) edition (ICD-10). RESULTS: Sixty eight percent of the patients with NCC suffered from a psychiatric disorder, as compared to 44% of those without NCC (P=0.02). Major depression and mixed anxiety depression were the two most common diagnoses. None of the patients was to found to suffer from a psychotic disorder. The most frequent site of brain lesion of NCC was the parietal lobe, followed by frontal lobes and disseminated lesions. Left sided lesions were associated with greater psychiatric morbidity. Focal seizures with or without secondary generalizations were present more frequently in patients with NCC whereas primary generalized seizures were more common in patients with idiopathic epilepsy (P=0.05). CONCLUSION: Psychiatric manifestations are more common in patients of epilepsy with NCC than those without NCC. The treating clinician need to be vigilant about the phenomenon. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3777348/ /pubmed/24082247 http://dx.doi.org/10.4103/0019-5545.117146 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Srivastava, Smita
Chadda, Rakesh Kumar
Bala, Kiran
Majumdar, Pradipta
A study of neuropsychiatric manifestations in patients of neurocysticercosis
title A study of neuropsychiatric manifestations in patients of neurocysticercosis
title_full A study of neuropsychiatric manifestations in patients of neurocysticercosis
title_fullStr A study of neuropsychiatric manifestations in patients of neurocysticercosis
title_full_unstemmed A study of neuropsychiatric manifestations in patients of neurocysticercosis
title_short A study of neuropsychiatric manifestations in patients of neurocysticercosis
title_sort study of neuropsychiatric manifestations in patients of neurocysticercosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777348/
https://www.ncbi.nlm.nih.gov/pubmed/24082247
http://dx.doi.org/10.4103/0019-5545.117146
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