Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2

Protein functions are largely affected by their conformations. This is exemplified in proteins containing modular domains. However, the evolutionary dynamics that define and adapt the conformation of such modular proteins remain elusive. Here we show that cis-interactions between the C-terminal phos...

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Detalles Bibliográficos
Autores principales: Sun, Jie, Lu, Shaoying, Ouyang, Mingxing, Lin, Li-Jung, Zhuo, Yue, Liu, Bo, Chien, Shu, Neel, Benjamin G., Wang, Yingxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777412/
https://www.ncbi.nlm.nih.gov/pubmed/23792876
http://dx.doi.org/10.1038/ncomms3037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777412/
https://www.ncbi.nlm.nih.gov/pubmed/23792876
http://dx.doi.org/10.1038/ncomms3037

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