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Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2
Protein functions are largely affected by their conformations. This is exemplified in proteins containing modular domains. However, the evolutionary dynamics that define and adapt the conformation of such modular proteins remain elusive. Here we show that cis-interactions between the C-terminal phos...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777412/ https://www.ncbi.nlm.nih.gov/pubmed/23792876 http://dx.doi.org/10.1038/ncomms3037 |