Role of ABC transporters in cancer chemotherapy

Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cance...

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Detalles Bibliográficos
Autores principales: Sun, Yue-Li, Patel, Atish, Kumar, Priyank, Chen, Zhe-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2012
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777472/
https://www.ncbi.nlm.nih.gov/pubmed/22257384
http://dx.doi.org/10.5732/cjc.011.10466
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author Sun, Yue-Li
Patel, Atish
Kumar, Priyank
Chen, Zhe-Sheng
author_facet Sun, Yue-Li
Patel, Atish
Kumar, Priyank
Chen, Zhe-Sheng
author_sort Sun, Yue-Li
collection PubMed
description Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR.
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spelling pubmed-37774722013-12-11 Role of ABC transporters in cancer chemotherapy Sun, Yue-Li Patel, Atish Kumar, Priyank Chen, Zhe-Sheng Chin J Cancer Editorial Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR. Sun Yat-sen University Cancer Center 2012-02 /pmc/articles/PMC3777472/ /pubmed/22257384 http://dx.doi.org/10.5732/cjc.011.10466 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Editorial
Sun, Yue-Li
Patel, Atish
Kumar, Priyank
Chen, Zhe-Sheng
Role of ABC transporters in cancer chemotherapy
title Role of ABC transporters in cancer chemotherapy
title_full Role of ABC transporters in cancer chemotherapy
title_fullStr Role of ABC transporters in cancer chemotherapy
title_full_unstemmed Role of ABC transporters in cancer chemotherapy
title_short Role of ABC transporters in cancer chemotherapy
title_sort role of abc transporters in cancer chemotherapy
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777472/
https://www.ncbi.nlm.nih.gov/pubmed/22257384
http://dx.doi.org/10.5732/cjc.011.10466
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AT patelatish roleofabctransportersincancerchemotherapy
AT kumarpriyank roleofabctransportersincancerchemotherapy
AT chenzhesheng roleofabctransportersincancerchemotherapy

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