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Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma
Serum enzymes that play potential roles in tumor growth have recently been reported to have prognostic relevance in a diverse array of tumors. However, prognosis-related serum enzymes are rarely reported for nasopharyngeal carcinoma (NPC). To clarify whether the level of serum enzymes is linked to t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sun Yat-sen University Cancer Center
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777475/ https://www.ncbi.nlm.nih.gov/pubmed/22237040 http://dx.doi.org/10.5732/cjc.011.10283 |
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author | Li, Guo Gao, Jin Tao, Ya-Lan Xu, Bing-Qing Tu, Zi-Wei Liu, Zhi-Gang Zeng, Mu-Sheng Xia, Yun-Fei |
author_facet | Li, Guo Gao, Jin Tao, Ya-Lan Xu, Bing-Qing Tu, Zi-Wei Liu, Zhi-Gang Zeng, Mu-Sheng Xia, Yun-Fei |
author_sort | Li, Guo |
collection | PubMed |
description | Serum enzymes that play potential roles in tumor growth have recently been reported to have prognostic relevance in a diverse array of tumors. However, prognosis-related serum enzymes are rarely reported for nasopharyngeal carcinoma (NPC). To clarify whether the level of serum enzymes is linked to the prognosis of NPC, we reviewed the pretreatment data of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and glutamyl transferase (GGT) in 533 newly diagnosed NPC patients who underwent radical radiotherapy between May 2002 and October 2003 at Sun Yat-sen University Cancer Center. Patients were grouped according to the upper limit of normal values of LDH, ALP, and GGT. The Kaplan-Meier method and log-rank test were used for selecting prognostic factors from clinical characteristics and serum enzymes, and the Chi-square test was applied to analyze the relationships of clinical characteristics and serum enzymes. Finally, a Cox proportional hazards model was used to identify the independent prognostic factors. We found that increased levels of LDH had poor effects on both overall survival and distant metastasis-free survival (P = 0.009 and 0.035, respectively), and increased pretreatment level of serum ALP had poor effects on both overall survival and local recurrence-free survival (P = 0.037 and 0.039, respectively). In multivariate analysis, increased LDH level was identified as an independent prognostic factor for overall survival. Therefore, we conclude that increased pretreatment serum LDH and ALP levels are poor prognostic factors for NPC. |
format | Online Article Text |
id | pubmed-3777475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-37774752013-12-11 Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma Li, Guo Gao, Jin Tao, Ya-Lan Xu, Bing-Qing Tu, Zi-Wei Liu, Zhi-Gang Zeng, Mu-Sheng Xia, Yun-Fei Chin J Cancer Original Article Serum enzymes that play potential roles in tumor growth have recently been reported to have prognostic relevance in a diverse array of tumors. However, prognosis-related serum enzymes are rarely reported for nasopharyngeal carcinoma (NPC). To clarify whether the level of serum enzymes is linked to the prognosis of NPC, we reviewed the pretreatment data of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and glutamyl transferase (GGT) in 533 newly diagnosed NPC patients who underwent radical radiotherapy between May 2002 and October 2003 at Sun Yat-sen University Cancer Center. Patients were grouped according to the upper limit of normal values of LDH, ALP, and GGT. The Kaplan-Meier method and log-rank test were used for selecting prognostic factors from clinical characteristics and serum enzymes, and the Chi-square test was applied to analyze the relationships of clinical characteristics and serum enzymes. Finally, a Cox proportional hazards model was used to identify the independent prognostic factors. We found that increased levels of LDH had poor effects on both overall survival and distant metastasis-free survival (P = 0.009 and 0.035, respectively), and increased pretreatment level of serum ALP had poor effects on both overall survival and local recurrence-free survival (P = 0.037 and 0.039, respectively). In multivariate analysis, increased LDH level was identified as an independent prognostic factor for overall survival. Therefore, we conclude that increased pretreatment serum LDH and ALP levels are poor prognostic factors for NPC. Sun Yat-sen University Cancer Center 2012-04 /pmc/articles/PMC3777475/ /pubmed/22237040 http://dx.doi.org/10.5732/cjc.011.10283 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Original Article Li, Guo Gao, Jin Tao, Ya-Lan Xu, Bing-Qing Tu, Zi-Wei Liu, Zhi-Gang Zeng, Mu-Sheng Xia, Yun-Fei Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma |
title | Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma |
title_full | Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma |
title_fullStr | Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma |
title_full_unstemmed | Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma |
title_short | Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma |
title_sort | increased pretreatment levels of serum ldh and alp as poor prognostic factors for nasopharyngeal carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777475/ https://www.ncbi.nlm.nih.gov/pubmed/22237040 http://dx.doi.org/10.5732/cjc.011.10283 |
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