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Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites

Differences between Hodgkin's lymphoma (HL) patients in China and Western countries are known to exist, but data on Chinese patients with HL are limited. It is not clear whether there are clinical and histological differences in patients with HL involving different extranodal sites. This is the...

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Autores principales: Li, Zhi-Ming, Zhu, Ying-Jie, Xia, Yi, Huang, Jia-Jia, Jiang, Wen-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777495/
https://www.ncbi.nlm.nih.gov/pubmed/22692069
http://dx.doi.org/10.5732/cjc.012.10008
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author Li, Zhi-Ming
Zhu, Ying-Jie
Xia, Yi
Huang, Jia-Jia
Jiang, Wen-Qi
author_facet Li, Zhi-Ming
Zhu, Ying-Jie
Xia, Yi
Huang, Jia-Jia
Jiang, Wen-Qi
author_sort Li, Zhi-Ming
collection PubMed
description Differences between Hodgkin's lymphoma (HL) patients in China and Western countries are known to exist, but data on Chinese patients with HL are limited. It is not clear whether there are clinical and histological differences in patients with HL involving different extranodal sites. This is the first study to analyze Chinese patients with HL involving different extranodal sites. We selected 22 HL patients with extranodal involvement from more than 250 previously untreated HL patients. Most patients were young males, and 20 of the 22 patients had stage IV disease. The major pathologic types were nodular sclerosis classical HL (NSCHL) and mixed cellularity classical HL (MCCHL). At diagnosis, the most commonly involved extranodal sites were the liver and lung, followed by the bones. There was no significant association between the international prognostic score (IPS) and survival in patients with different extranodal sites. Our data showed the overall survival (OS) and disease-free survival (DFS) rates of low-risk group (IPS = 0-2) were relatively higher than those of high-risk group (IPS ≥ 3), but the IPS did not show predictive power for survival. Although HL with extranodal involvement is rare, it should be considered as a unique form of HL.
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spelling pubmed-37774952013-12-11 Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites Li, Zhi-Ming Zhu, Ying-Jie Xia, Yi Huang, Jia-Jia Jiang, Wen-Qi Chin J Cancer Original Article Differences between Hodgkin's lymphoma (HL) patients in China and Western countries are known to exist, but data on Chinese patients with HL are limited. It is not clear whether there are clinical and histological differences in patients with HL involving different extranodal sites. This is the first study to analyze Chinese patients with HL involving different extranodal sites. We selected 22 HL patients with extranodal involvement from more than 250 previously untreated HL patients. Most patients were young males, and 20 of the 22 patients had stage IV disease. The major pathologic types were nodular sclerosis classical HL (NSCHL) and mixed cellularity classical HL (MCCHL). At diagnosis, the most commonly involved extranodal sites were the liver and lung, followed by the bones. There was no significant association between the international prognostic score (IPS) and survival in patients with different extranodal sites. Our data showed the overall survival (OS) and disease-free survival (DFS) rates of low-risk group (IPS = 0-2) were relatively higher than those of high-risk group (IPS ≥ 3), but the IPS did not show predictive power for survival. Although HL with extranodal involvement is rare, it should be considered as a unique form of HL. Sun Yat-sen University Cancer Center 2012-07 /pmc/articles/PMC3777495/ /pubmed/22692069 http://dx.doi.org/10.5732/cjc.012.10008 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Original Article
Li, Zhi-Ming
Zhu, Ying-Jie
Xia, Yi
Huang, Jia-Jia
Jiang, Wen-Qi
Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites
title Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites
title_full Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites
title_fullStr Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites
title_full_unstemmed Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites
title_short Clinical characteristics of the patients with Hodgkin's lymphoma involving extranodal sites
title_sort clinical characteristics of the patients with hodgkin's lymphoma involving extranodal sites
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777495/
https://www.ncbi.nlm.nih.gov/pubmed/22692069
http://dx.doi.org/10.5732/cjc.012.10008
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