Strategies for targeting the DNA damage response for cancer therapeutics

The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage res...

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Detalles Bibliográficos
Autores principales: Zhang, Dan, Wang, Hai-Bo, Brinkman, Kathryn L., Han, Su-Xia, Xu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2012
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777509/
https://www.ncbi.nlm.nih.gov/pubmed/22704491
http://dx.doi.org/10.5732/cjc.012.10087
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author Zhang, Dan
Wang, Hai-Bo
Brinkman, Kathryn L.
Han, Su-Xia
Xu, Bo
author_facet Zhang, Dan
Wang, Hai-Bo
Brinkman, Kathryn L.
Han, Su-Xia
Xu, Bo
author_sort Zhang, Dan
collection PubMed
description The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
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spelling pubmed-37775092013-12-11 Strategies for targeting the DNA damage response for cancer therapeutics Zhang, Dan Wang, Hai-Bo Brinkman, Kathryn L. Han, Su-Xia Xu, Bo Chin J Cancer Editorial The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality. Sun Yat-sen University Cancer Center 2012-08 /pmc/articles/PMC3777509/ /pubmed/22704491 http://dx.doi.org/10.5732/cjc.012.10087 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Editorial
Zhang, Dan
Wang, Hai-Bo
Brinkman, Kathryn L.
Han, Su-Xia
Xu, Bo
Strategies for targeting the DNA damage response for cancer therapeutics
title Strategies for targeting the DNA damage response for cancer therapeutics
title_full Strategies for targeting the DNA damage response for cancer therapeutics
title_fullStr Strategies for targeting the DNA damage response for cancer therapeutics
title_full_unstemmed Strategies for targeting the DNA damage response for cancer therapeutics
title_short Strategies for targeting the DNA damage response for cancer therapeutics
title_sort strategies for targeting the dna damage response for cancer therapeutics
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777509/
https://www.ncbi.nlm.nih.gov/pubmed/22704491
http://dx.doi.org/10.5732/cjc.012.10087
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