Repressing malic enzyme 1 redirects glucose metabolism, unbalances the redox state, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines

A large amount of nicotinamide adenine dinucleotide phosphate (NADPH) is required for fatty acid synthesis and maintenance of the redox state in cancer cells. Malic enzyme 1 (ME1)-dependent NADPH production is one of the three pathways that contribute to the formation of the cytosolic NADPH pool. ME...

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Detalles Bibliográficos
Autores principales: Zheng, Fang-Jing, Ye, Hao-Bin, Wu, Man-Si, Lian, Yi-Fan, Qian, Chao-Nan, Zeng, Yi-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777517/
https://www.ncbi.nlm.nih.gov/pubmed/23114090
http://dx.doi.org/10.5732/cjc.012.10088

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