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Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()

Amyloid imaging is currently introduced to the market for clinical use. We will review the evidence demonstrating that the different amyloid PET ligands that are currently available are valid biomarkers for Alzheimer-related β amyloidosis. Based on recent findings from cross-sectional and longitudin...

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Autores principales: Vandenberghe, Rik, Adamczuk, Katarzyna, Dupont, Patrick, Laere, Koen Van, Chételat, Gaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777773/
https://www.ncbi.nlm.nih.gov/pubmed/24179802
http://dx.doi.org/10.1016/j.nicl.2013.03.014
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author Vandenberghe, Rik
Adamczuk, Katarzyna
Dupont, Patrick
Laere, Koen Van
Chételat, Gaël
author_facet Vandenberghe, Rik
Adamczuk, Katarzyna
Dupont, Patrick
Laere, Koen Van
Chételat, Gaël
author_sort Vandenberghe, Rik
collection PubMed
description Amyloid imaging is currently introduced to the market for clinical use. We will review the evidence demonstrating that the different amyloid PET ligands that are currently available are valid biomarkers for Alzheimer-related β amyloidosis. Based on recent findings from cross-sectional and longitudinal imaging studies using different modalities, we will incorporate amyloid imaging into a multidimensional model of Alzheimer's disease. Aside from the critical role in improving clinical trial design for amyloid-lowering drugs, we will also propose a tentative algorithm for when it may be useful in a memory clinic environment. Gaps in our evidence-based knowledge of the added value of amyloid imaging in a clinical context will be identified and will need to be addressed by dedicated studies of clinical utility.
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spelling pubmed-37777732013-10-31 Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease() Vandenberghe, Rik Adamczuk, Katarzyna Dupont, Patrick Laere, Koen Van Chételat, Gaël Neuroimage Clin Review Article Amyloid imaging is currently introduced to the market for clinical use. We will review the evidence demonstrating that the different amyloid PET ligands that are currently available are valid biomarkers for Alzheimer-related β amyloidosis. Based on recent findings from cross-sectional and longitudinal imaging studies using different modalities, we will incorporate amyloid imaging into a multidimensional model of Alzheimer's disease. Aside from the critical role in improving clinical trial design for amyloid-lowering drugs, we will also propose a tentative algorithm for when it may be useful in a memory clinic environment. Gaps in our evidence-based knowledge of the added value of amyloid imaging in a clinical context will be identified and will need to be addressed by dedicated studies of clinical utility. Elsevier 2013-04-06 /pmc/articles/PMC3777773/ /pubmed/24179802 http://dx.doi.org/10.1016/j.nicl.2013.03.014 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review Article
Vandenberghe, Rik
Adamczuk, Katarzyna
Dupont, Patrick
Laere, Koen Van
Chételat, Gaël
Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()
title Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()
title_full Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()
title_fullStr Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()
title_full_unstemmed Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()
title_short Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease()
title_sort amyloid pet in clinical practice: its place in the multidimensional space of alzheimer's disease()
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777773/
https://www.ncbi.nlm.nih.gov/pubmed/24179802
http://dx.doi.org/10.1016/j.nicl.2013.03.014
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