Ultra-sensitive fluorescent proteins for imaging neuronal activity

Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultra-sensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured neurons and in zebrafish, flies, and mice in vivo....

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Detalles Bibliográficos
Autores principales: Chen, Tsai-Wen, Wardill, Trevor J., Sun, Yi, Pulver, Stefan R., Renninger, Sabine L., Baohan, Amy, Schreiter, Eric R., Kerr, Rex A., Orger, Michael B., Jayaraman, Vivek, Looger, Loren L., Svoboda, Karel, Kim, Douglas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777791/
https://www.ncbi.nlm.nih.gov/pubmed/23868258
http://dx.doi.org/10.1038/nature12354

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