Cargando…

Predictive Modeling of In Vivo Response to Gemcitabine in Pancreatic Cancer

A clear contradiction exists between cytotoxic in-vitro studies demonstrating effectiveness of Gemcitabine to curtail pancreatic cancer and in-vivo studies failing to show Gemcitabine as an effective treatment. The outcome of chemotherapy in metastatic stages, where surgery is no longer viable, show...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, James J., Huang, Justin, England, Christopher G., McNally, Lacey R., Frieboes, Hermann B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777914/ https://www.ncbi.nlm.nih.gov/pubmed/24068909 http://dx.doi.org/10.1371/journal.pcbi.1003231

Ejemplares similares

Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging
por: England, Christopher G., et al.
Publicado: (2015)

Enhanced penetration into 3D cell culture using two and three layered gold nanoparticles
por: England, Christopher G, et al.
Publicado: (2013)

Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography
por: Yin, Wenyuan, et al.
Publicado: (2015)

Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer
por: Walker, Leslie R, et al.
Publicado: (2014)

Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo
por: Thomas, Alexandra, et al.
Publicado: (2020)

Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models
por: Mohammad, Jiyan, et al.
Publicado: (2017)

In vivo tracking of orally-administered particles within the gastrointestinal tract of murine models using multispectral optoacoustic tomography
por: Bhutiani, Neal, et al.
Publicado: (2018)

Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer
por: Michalski, C W, et al.
Publicado: (2008)

Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models
por: D'Aronzo, Martina, et al.
Publicado: (2015)

Determinants of gemcitabine response in pancreatic cancer: are we there?
por: Fitzpatrick, Orla M., et al.
Publicado: (2023)

Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis
por: Frieboes, Hermann B., et al.
Publicado: (2020)

Huaier increases the antitumor effect of gemcitabine on pancreatic cancer in vitro and in vivo
por: Chen, Tao, et al.
Publicado: (2021)

Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging
por: Laramie, Matt D., et al.
Publicado: (2018)

Circular RNA Signature Predicts Gemcitabine Resistance of Pancreatic Ductal Adenocarcinoma
por: Shao, Feng, et al.
Publicado: (2018)

Predictive Values of Blood-Based RNA Signatures for the Gemcitabine Response in Advanced Pancreatic Cancer
por: Piquemal, David, et al.
Publicado: (2020)

ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer
por: Yu, Pian, et al.
Publicado: (2022)

Inhibitory effect of metformin combined with gemcitabine on pancreatic cancer cells in vitro and in vivo
por: Shi, Yuqi, et al.
Publicado: (2016)

Pomalidomide enhanced gemcitabine and nab-paclitaxel on pancreatic cancer both in vitro and in vivo
por: Saito, Nobuhiro, et al.
Publicado: (2018)

Barriers and opportunities for gemcitabine in pancreatic cancer therapy
por: Beutel, Alica K., et al.
Publicado: (2023)

Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo
por: Bapiro, T E, et al.
Publicado: (2014)

Pancreatic Cancer Chemoresistance to Gemcitabine
por: Amrutkar, Manoj, et al.
Publicado: (2017)

A Computational Model for Predicting Nanoparticle Accumulation in Tumor Vasculature
por: Frieboes, Hermann B., et al.
Publicado: (2013)

Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation
por: Loizou, George, et al.
Publicado: (2022)

Cytotoxicity of adriamycin to tumour cells in vivo and in vitro.
por: Martin, W. M., et al.
Publicado: (1980)

Evaluation of stacked ensemble model performance to predict clinical outcomes: A COVID-19 study
por: Kablan, Rianne, et al.
Publicado: (2023)

TM4SF1 Promotes Gemcitabine Resistance of Pancreatic Cancer In Vitro and In Vivo
por: Cao, Jia, et al.
Publicado: (2015)

Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles
por: Curtis, Louis T., et al.
Publicado: (2015)

Gemcitabine plus cisplatin versus gemcitabine alone in the treatment of pancreatic cancer: a meta-analysis
por: Ouyang, Guoqing, et al.
Publicado: (2016)

A Computational Workflow for Probabilistic Quantitative in Vitro to in Vivo Extrapolation
por: McNally, Kevin, et al.
Publicado: (2018)

An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer
por: Zhou, Zhijun, et al.
Publicado: (2021)

MicroRNA Expression as a Predictive Marker for Gemcitabine Response after Surgical Resection of Pancreatic Cancer
por: Ohuchida, Kenoki, et al.
Publicado: (2011)

Overcoming negative predictions of microRNA expressions to gemcitabine response with FOLFIRINOX in advanced pancreatic cancer patients
por: Schlick, Konstantin, et al.
Publicado: (2020)

Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro
por: McNally, Karen, et al.
Publicado: (2014)

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma
por: Palam, L R, et al.
Publicado: (2015)

Real-world outcomes of adjuvant gemcitabine versus gemcitabine plus capecitabine for resected pancreatic ductal adenocarcinoma
por: Kang, Sora, et al.
Publicado: (2022)

Erlotinib plus gemcitabine versus gemcitabine for pancreatic cancer: real-world analysis of Korean national database
por: Shin, Sangjin, et al.
Publicado: (2016)

Chronic Ketamine Reduces the Peak Frequency of Gamma Oscillations in Mouse Prefrontal Cortex Ex vivo
por: McNally, James M., et al.
Publicado: (2013)

An in vitro and in vivo study of gemcitabine-loaded albumin nanoparticles in a pancreatic cancer cell line
por: Yu, Xinzhe, et al.
Publicado: (2015)

The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
por: Doello, Kevin, et al.
Publicado: (2021)

Analysis of the Ex Vivo and In Vivo Antiretroviral Activity of Gemcitabine
por: Clouser, Christine L., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_l2umdl9p96ip43pa5hqrf3v3k0