Differential Protective Effects of Exenatide, an Agonist of GLP-1 Receptor and Piragliatin, a Glucokinase Activator in Beta Cell Response to Streptozotocin-Induced and Endoplasmic Reticulum Stresses

BACKGROUND: Agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucokinase activators (GKA) act as antidiabetic agents by their ability protect beta cells, and stimulate insulin secretion. Oxidative and endoplasmic reticulum (ER) stresses aggravate type 2 diabetes by causing beta cell loss. I...

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Detalles Bibliográficos
Autores principales: Kim, Mi-Kyung, Cho, Jin-Hwan, Lee, Jae-Jin, Cheong, Ye-Hwang, Son, Moon-Ho, Lee, Kong-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777936/
https://www.ncbi.nlm.nih.gov/pubmed/24069189
http://dx.doi.org/10.1371/journal.pone.0073340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777936/
https://www.ncbi.nlm.nih.gov/pubmed/24069189
http://dx.doi.org/10.1371/journal.pone.0073340

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