Cargando…

Cardiomyocyte MEA Data Analysis (CardioMDA) – A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes

Cardiac safety pharmacology requires in-vitro testing of all drug candidates before clinical trials in order to ensure they are screened for cardio-toxic effects which may result in severe arrhythmias. Micro-electrode arrays (MEA) serve as a complement to current in-vitro methods for drug safety tes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pradhapan, Paruthi, Kuusela, Jukka, Viik, Jari, Aalto-Setälä, Katriina, Hyttinen, Jari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777951/ https://www.ncbi.nlm.nih.gov/pubmed/24069215 http://dx.doi.org/10.1371/journal.pone.0073637

Ejemplares similares

Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation
por: Ahola, Antti, et al.
Publicado: (2014)

The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes
por: Kuusela, Jukka, et al.
Publicado: (2016)

Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes
por: Kuusela, Jukka, et al.
Publicado: (2017)

Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation
por: Kujala, Kirsi, et al.
Publicado: (2012)

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
por: Paci, Michelangelo, et al.
Publicado: (2018)

Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes
por: Kuusela, Jukka, et al.
Publicado: (2016)

Mechanically Biomimetic Gelatin–Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes
por: Koivisto, Janne T., et al.
Publicado: (2019)

hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells
por: Shah, Disheet, et al.
Publicado: (2020)

Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning
por: Juhola, Martti, et al.
Publicado: (2020)

Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations
por: Kiviaho, Anna L., et al.
Publicado: (2015)

Divergent effects of adrenaline in human induced pluripotent stem cell-derived cardiomyocytes obtained from hypertrophic cardiomyopathy
por: Prajapati, Chandra, et al.
Publicado: (2018)

Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis
por: Dunham, Christopher S., et al.
Publicado: (2022)

Simultaneous Measurement of Contraction and Calcium Transients in Stem Cell Derived Cardiomyocytes
por: Ahola, A., et al.
Publicado: (2017)

Simultaneous recordings of action potentials and calcium transients from human induced pluripotent stem cell derived cardiomyocytes
por: Prajapati, Chandra, et al.
Publicado: (2018)

Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality—an experimental study on the FINCAVAS cohort
por: Pradhapan, Paruthi, et al.
Publicado: (2014)

Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct
por: Vuorenpää, Hanna, et al.
Publicado: (2017)

A mathematical model of hiPSC cardiomyocytes electromechanics
por: Forouzandehmehr, Mohamadamin, et al.
Publicado: (2021)

Novel Analysis Software for Detecting and Classifying Ca(2+) Transient Abnormalities in Stem Cell-Derived Cardiomyocytes
por: Penttinen, Kirsi, et al.
Publicado: (2015)

Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes
por: Kreutzer, Joose, et al.
Publicado: (2019)

Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Gaballah, Mahmoud, et al.
Publicado: (2022)

2D and 3D Self-Assembling Nanofiber Hydrogels for Cardiomyocyte Culture
por: Ikonen, Liisa, et al.
Publicado: (2013)

Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation
por: Häkli, Martta, et al.
Publicado: (2022)

Polyethylene Terephthalate Textiles Enhance the Structural Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Pekkanen-Mattila, Mari, et al.
Publicado: (2019)

Multifocal optical projection microscopy enables label-free 3D measurement of cardiomyocyte cluster contractility
por: Belay, Birhanu, et al.
Publicado: (2023)

Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach
por: Paci, Michelangelo, et al.
Publicado: (2017)

Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes
por: Paci, Michelangelo, et al.
Publicado: (2018)

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)
por: Sala, Luca, et al.
Publicado: (2017)

Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip
por: Häkli, Martta, et al.
Publicado: (2022)

HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity
por: Penttinen, Kirsi, et al.
Publicado: (2023)

Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
por: Maria Cherian, Reeja, et al.
Publicado: (2022)

Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes
por: Björk, Susann, et al.
Publicado: (2017)

Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients
por: Pölönen, R. P., et al.
Publicado: (2018)

Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy
por: Ojala, Marisa, et al.
Publicado: (2016)

The Junctophilin-2 Mutation p.(Thr161Lys) Is Associated with Hypertrophic Cardiomyopathy Using Patient-Specific iPS Cardiomyocytes and Demonstrates Prolonged Action Potential and Increased Arrhythmogenicity
por: Valtonen, Joona, et al.
Publicado: (2023)

MultiElec: A MATLAB Based Application for MEA Data Analysis
por: Georgiadis, Vassilis, et al.
Publicado: (2015)

Cardiac Differentiation of Pluripotent Stem Cells
por: Rajala, Kristiina, et al.
Publicado: (2011)

Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures
por: Suominen, Siiri, et al.
Publicado: (2023)

Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges
por: Aalto-Setälä, Katriina, et al.
Publicado: (2009)

CytoSpectre: a tool for spectral analysis of oriented structures on cellular and subcellular levels
por: Kartasalo, Kimmo, et al.
Publicado: (2015)

Mea Cuba
por: Cabrera Infante, G. (Guillermo), 1929-2005
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_kndebogiseg2g5vpl37t5fit90