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The Inhibitory Helix Controls the Intramolecular Conformational Switching of the C-Terminus of STIM1

Store-operated Ca(2+) entry (SOCE) is a critical Ca(2+) signaling pathway in many cell types. After sensing Ca(2+) store depletion in the endoplasmic reticulum (ER) lumen, STIM1 (STromal Interaction Molecule 1) oligomerizes and then interacts with and activates the Orai1 calcium channel. Our previou...

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Detalles Bibliográficos
Autores principales:	Cui, Boyang, Yang, Xue, Li, Siwei, Lin, Zhijie, Wang, Zheng, Dong, Cheng, Shen, Yuequan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777995/ https://www.ncbi.nlm.nih.gov/pubmed/24069340 http://dx.doi.org/10.1371/journal.pone.0074735

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