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The Prp19 Complex Directly Functions in Mitotic Spindle Assembly

The conserved Prp19 (pre-RNA processing 19) complex is required for pre-mRNA splicing in eukaryotic nuclei. Recent RNAi screens indicated that knockdown of Prp19 complex subunits strongly delays cell proliferation. Here we show that knockdown of the smallest subunit, BCAS2/Spf27, destabilizes the en...

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Detalles Bibliográficos
Autores principales:	Hofmann, Jennifer C., Tegha-Dunghu, Justus, Dräger, Stefanie, Will, Cindy L., Lührmann, Reinhard, Gruss, Oliver J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777999/ https://www.ncbi.nlm.nih.gov/pubmed/24069358 http://dx.doi.org/10.1371/journal.pone.0074851

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