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Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study
Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Ana...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778226/ https://www.ncbi.nlm.nih.gov/pubmed/23715889 http://dx.doi.org/10.1007/s00403-013-1360-7 |
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author | Baspeyras, Martine Rouvrais, Céline Liégard, Laetitia Delalleau, Alexandre Letellier, Sandrine Bacle, Irène Courrech, Laetitia Murat, Pascale Mengeaud, Valérie Schmitt, Anne-Marie |
author_facet | Baspeyras, Martine Rouvrais, Céline Liégard, Laetitia Delalleau, Alexandre Letellier, Sandrine Bacle, Irène Courrech, Laetitia Murat, Pascale Mengeaud, Valérie Schmitt, Anne-Marie |
author_sort | Baspeyras, Martine |
collection | PubMed |
description | Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 × 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (−10.9 %, p = 0.026) and 3M (−10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (−8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 %, p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance. |
format | Online Article Text |
id | pubmed-3778226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-37782262013-09-25 Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study Baspeyras, Martine Rouvrais, Céline Liégard, Laetitia Delalleau, Alexandre Letellier, Sandrine Bacle, Irène Courrech, Laetitia Murat, Pascale Mengeaud, Valérie Schmitt, Anne-Marie Arch Dermatol Res Original Paper Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 × 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (−10.9 %, p = 0.026) and 3M (−10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (−8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 %, p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance. Springer Berlin Heidelberg 2013-05-29 2013 /pmc/articles/PMC3778226/ /pubmed/23715889 http://dx.doi.org/10.1007/s00403-013-1360-7 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Paper Baspeyras, Martine Rouvrais, Céline Liégard, Laetitia Delalleau, Alexandre Letellier, Sandrine Bacle, Irène Courrech, Laetitia Murat, Pascale Mengeaud, Valérie Schmitt, Anne-Marie Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study |
title | Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study |
title_full | Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study |
title_fullStr | Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study |
title_full_unstemmed | Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study |
title_short | Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study |
title_sort | clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778226/ https://www.ncbi.nlm.nih.gov/pubmed/23715889 http://dx.doi.org/10.1007/s00403-013-1360-7 |
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