Cargando…

Abnormal brain synchrony in Down Syndrome()

Down Syndrome is the most common genetic cause for intellectual disability, yet the pathophysiology of cognitive impairment in Down Syndrome is unknown. We compared fMRI scans of 15 individuals with Down Syndrome to 14 typically developing control subjects while they viewed 50 min of cartoon video c...

Descripción completa

Detalles Bibliográficos
Autores principales: Anderson, Jeffrey S., Nielsen, Jared A., Ferguson, Michael A., Burback, Melissa C., Cox, Elizabeth T., Dai, Li, Gerig, Guido, Edgin, Jamie O., Korenberg, Julie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778249/
https://www.ncbi.nlm.nih.gov/pubmed/24179822
http://dx.doi.org/10.1016/j.nicl.2013.05.006
_version_ 1782285079665442816
author Anderson, Jeffrey S.
Nielsen, Jared A.
Ferguson, Michael A.
Burback, Melissa C.
Cox, Elizabeth T.
Dai, Li
Gerig, Guido
Edgin, Jamie O.
Korenberg, Julie R.
author_facet Anderson, Jeffrey S.
Nielsen, Jared A.
Ferguson, Michael A.
Burback, Melissa C.
Cox, Elizabeth T.
Dai, Li
Gerig, Guido
Edgin, Jamie O.
Korenberg, Julie R.
author_sort Anderson, Jeffrey S.
collection PubMed
description Down Syndrome is the most common genetic cause for intellectual disability, yet the pathophysiology of cognitive impairment in Down Syndrome is unknown. We compared fMRI scans of 15 individuals with Down Syndrome to 14 typically developing control subjects while they viewed 50 min of cartoon video clips. There was widespread increased synchrony between brain regions, with only a small subset of strong, distant connections showing underconnectivity in Down Syndrome. Brain regions showing negative correlations were less anticorrelated and were among the most strongly affected connections in the brain. Increased correlation was observed between all of the distributed brain networks studied, with the strongest internetwork correlation in subjects with the lowest performance IQ. A functional parcellation of the brain showed simplified network structure in Down Syndrome organized by local connectivity. Despite increased interregional synchrony, intersubject correlation to the cartoon stimuli was lower in Down Syndrome, indicating that increased synchrony had a temporal pattern that was not in response to environmental stimuli, but idiosyncratic to each Down Syndrome subject. Short-range, increased synchrony was not observed in a comparison sample of 447 autism vs. 517 control subjects from the Autism Brain Imaging Exchange (ABIDE) collection of resting state fMRI data, and increased internetwork synchrony was only observed between the default mode and attentional networks in autism. These findings suggest immature development of connectivity in Down Syndrome with impaired ability to integrate information from distant brain regions into coherent distributed networks.
format Online
Article
Text
id pubmed-3778249
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-37782492013-10-31 Abnormal brain synchrony in Down Syndrome() Anderson, Jeffrey S. Nielsen, Jared A. Ferguson, Michael A. Burback, Melissa C. Cox, Elizabeth T. Dai, Li Gerig, Guido Edgin, Jamie O. Korenberg, Julie R. Neuroimage Clin Article Down Syndrome is the most common genetic cause for intellectual disability, yet the pathophysiology of cognitive impairment in Down Syndrome is unknown. We compared fMRI scans of 15 individuals with Down Syndrome to 14 typically developing control subjects while they viewed 50 min of cartoon video clips. There was widespread increased synchrony between brain regions, with only a small subset of strong, distant connections showing underconnectivity in Down Syndrome. Brain regions showing negative correlations were less anticorrelated and were among the most strongly affected connections in the brain. Increased correlation was observed between all of the distributed brain networks studied, with the strongest internetwork correlation in subjects with the lowest performance IQ. A functional parcellation of the brain showed simplified network structure in Down Syndrome organized by local connectivity. Despite increased interregional synchrony, intersubject correlation to the cartoon stimuli was lower in Down Syndrome, indicating that increased synchrony had a temporal pattern that was not in response to environmental stimuli, but idiosyncratic to each Down Syndrome subject. Short-range, increased synchrony was not observed in a comparison sample of 447 autism vs. 517 control subjects from the Autism Brain Imaging Exchange (ABIDE) collection of resting state fMRI data, and increased internetwork synchrony was only observed between the default mode and attentional networks in autism. These findings suggest immature development of connectivity in Down Syndrome with impaired ability to integrate information from distant brain regions into coherent distributed networks. Elsevier 2013-05-24 /pmc/articles/PMC3778249/ /pubmed/24179822 http://dx.doi.org/10.1016/j.nicl.2013.05.006 Text en © 2013 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Anderson, Jeffrey S.
Nielsen, Jared A.
Ferguson, Michael A.
Burback, Melissa C.
Cox, Elizabeth T.
Dai, Li
Gerig, Guido
Edgin, Jamie O.
Korenberg, Julie R.
Abnormal brain synchrony in Down Syndrome()
title Abnormal brain synchrony in Down Syndrome()
title_full Abnormal brain synchrony in Down Syndrome()
title_fullStr Abnormal brain synchrony in Down Syndrome()
title_full_unstemmed Abnormal brain synchrony in Down Syndrome()
title_short Abnormal brain synchrony in Down Syndrome()
title_sort abnormal brain synchrony in down syndrome()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778249/
https://www.ncbi.nlm.nih.gov/pubmed/24179822
http://dx.doi.org/10.1016/j.nicl.2013.05.006
work_keys_str_mv AT andersonjeffreys abnormalbrainsynchronyindownsyndrome
AT nielsenjareda abnormalbrainsynchronyindownsyndrome
AT fergusonmichaela abnormalbrainsynchronyindownsyndrome
AT burbackmelissac abnormalbrainsynchronyindownsyndrome
AT coxelizabetht abnormalbrainsynchronyindownsyndrome
AT daili abnormalbrainsynchronyindownsyndrome
AT gerigguido abnormalbrainsynchronyindownsyndrome
AT edginjamieo abnormalbrainsynchronyindownsyndrome
AT korenbergjulier abnormalbrainsynchronyindownsyndrome