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Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?()
The objective of our study was to evaluate whether cognitively normal (CN) elderly participants showing elevated cortical beta-amyloid (Aβ) deposition have a consistent neuroanatomical signature of brain atrophy that may characterize preclinical Alzheimer's disease (AD). 115 CN participants who...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778266/ https://www.ncbi.nlm.nih.gov/pubmed/24179779 http://dx.doi.org/10.1016/j.nicl.2013.01.006 |
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author | Whitwell, Jennifer L. Tosakulwong, Nirubol Weigand, Stephen D. Senjem, Matthew L. Lowe, Val J. Gunter, Jeffrey L. Boeve, Bradley F. Knopman, David S. Dickerson, Bradford C. Petersen, Ronald C. Jack, Clifford R. |
author_facet | Whitwell, Jennifer L. Tosakulwong, Nirubol Weigand, Stephen D. Senjem, Matthew L. Lowe, Val J. Gunter, Jeffrey L. Boeve, Bradley F. Knopman, David S. Dickerson, Bradford C. Petersen, Ronald C. Jack, Clifford R. |
author_sort | Whitwell, Jennifer L. |
collection | PubMed |
description | The objective of our study was to evaluate whether cognitively normal (CN) elderly participants showing elevated cortical beta-amyloid (Aβ) deposition have a consistent neuroanatomical signature of brain atrophy that may characterize preclinical Alzheimer's disease (AD). 115 CN participants who were Aβ-positive (CN +) by amyloid PET imaging; 115 CN participants who were Aβ-negative (CN −); and 88 Aβ-positive mild cognitive impairment or AD participants (MCI/AD +) were identified. Cortical thickness (FreeSurfer) and gray matter volume (SPM5) were measured for 28 regions-of-interest (ROIs) across the brain and compared across groups. ROIs that best discriminated CN − from CN + differed for FreeSurfer cortical thickness and SPM5 gray matter volume. Group-wise discrimination was poor with a high degree of uncertainty in terms of the rank ordering of ROIs. In contrast, both techniques showed strong and consistent findings comparing MCI/AD + to both CN − and CN + groups, with entorhinal cortex, middle and inferior temporal lobe, inferior parietal lobe, and hippocampus providing the best discrimination for both techniques. Concordance across techniques was higher for the CN − and CN + versus MCI/AD + comparisons, compared to the CN − versus CN + comparison. The weak and inconsistent nature of the findings across technique in this study cast doubt on the existence of a reliable neuroanatomical signature of preclinical AD in elderly PiB-positive CN participants. |
format | Online Article Text |
id | pubmed-3778266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-37782662013-10-31 Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() Whitwell, Jennifer L. Tosakulwong, Nirubol Weigand, Stephen D. Senjem, Matthew L. Lowe, Val J. Gunter, Jeffrey L. Boeve, Bradley F. Knopman, David S. Dickerson, Bradford C. Petersen, Ronald C. Jack, Clifford R. Neuroimage Clin Article The objective of our study was to evaluate whether cognitively normal (CN) elderly participants showing elevated cortical beta-amyloid (Aβ) deposition have a consistent neuroanatomical signature of brain atrophy that may characterize preclinical Alzheimer's disease (AD). 115 CN participants who were Aβ-positive (CN +) by amyloid PET imaging; 115 CN participants who were Aβ-negative (CN −); and 88 Aβ-positive mild cognitive impairment or AD participants (MCI/AD +) were identified. Cortical thickness (FreeSurfer) and gray matter volume (SPM5) were measured for 28 regions-of-interest (ROIs) across the brain and compared across groups. ROIs that best discriminated CN − from CN + differed for FreeSurfer cortical thickness and SPM5 gray matter volume. Group-wise discrimination was poor with a high degree of uncertainty in terms of the rank ordering of ROIs. In contrast, both techniques showed strong and consistent findings comparing MCI/AD + to both CN − and CN + groups, with entorhinal cortex, middle and inferior temporal lobe, inferior parietal lobe, and hippocampus providing the best discrimination for both techniques. Concordance across techniques was higher for the CN − and CN + versus MCI/AD + comparisons, compared to the CN − versus CN + comparison. The weak and inconsistent nature of the findings across technique in this study cast doubt on the existence of a reliable neuroanatomical signature of preclinical AD in elderly PiB-positive CN participants. Elsevier 2013-01-24 /pmc/articles/PMC3778266/ /pubmed/24179779 http://dx.doi.org/10.1016/j.nicl.2013.01.006 Text en © 2013 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Whitwell, Jennifer L. Tosakulwong, Nirubol Weigand, Stephen D. Senjem, Matthew L. Lowe, Val J. Gunter, Jeffrey L. Boeve, Bradley F. Knopman, David S. Dickerson, Bradford C. Petersen, Ronald C. Jack, Clifford R. Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() |
title | Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() |
title_full | Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() |
title_fullStr | Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() |
title_full_unstemmed | Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() |
title_short | Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() |
title_sort | does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778266/ https://www.ncbi.nlm.nih.gov/pubmed/24179779 http://dx.doi.org/10.1016/j.nicl.2013.01.006 |
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