Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study

BACKGROUND: Chronic lymphocytic leukaemia (CLL) patients have an increased risk of other malignancies. This may be due to surveillance bias, treatment or immunosuppression. METHODS: Cohort study of 612 consecutively diagnosed CLL patients in a Canadian province, with comparisons to follicular lympho...

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Autores principales: Beiggi, S, Johnston, J B, Seftel, M D, Pitz, M W, Kumar, R, Banerji, V, J Griffith, E, Gibson, S B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778273/
https://www.ncbi.nlm.nih.gov/pubmed/23860531
http://dx.doi.org/10.1038/bjc.2013.381
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author Beiggi, S
Johnston, J B
Seftel, M D
Pitz, M W
Kumar, R
Banerji, V
J Griffith, E
Gibson, S B
author_facet Beiggi, S
Johnston, J B
Seftel, M D
Pitz, M W
Kumar, R
Banerji, V
J Griffith, E
Gibson, S B
author_sort Beiggi, S
collection PubMed
description BACKGROUND: Chronic lymphocytic leukaemia (CLL) patients have an increased risk of other malignancies. This may be due to surveillance bias, treatment or immunosuppression. METHODS: Cohort study of 612 consecutively diagnosed CLL patients in a Canadian province, with comparisons to follicular lymphoma (FL) patients. RESULTS: Treated CLL patients had a 1.7-fold increased risk of second cancers compared with untreated CLL patients. As compared with untreated FL patients, untreated CLL patients had a two-fold increased incidence of second malignancies. CONCLUSION: Chronic lymphocytic leukaemia patients have an inherent predisposition to second cancers and the incidence is further increased by treatment.
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spelling pubmed-37782732014-09-03 Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study Beiggi, S Johnston, J B Seftel, M D Pitz, M W Kumar, R Banerji, V J Griffith, E Gibson, S B Br J Cancer Short Communication BACKGROUND: Chronic lymphocytic leukaemia (CLL) patients have an increased risk of other malignancies. This may be due to surveillance bias, treatment or immunosuppression. METHODS: Cohort study of 612 consecutively diagnosed CLL patients in a Canadian province, with comparisons to follicular lymphoma (FL) patients. RESULTS: Treated CLL patients had a 1.7-fold increased risk of second cancers compared with untreated CLL patients. As compared with untreated FL patients, untreated CLL patients had a two-fold increased incidence of second malignancies. CONCLUSION: Chronic lymphocytic leukaemia patients have an inherent predisposition to second cancers and the incidence is further increased by treatment. Nature Publishing Group 2013-09-03 2013-07-16 /pmc/articles/PMC3778273/ /pubmed/23860531 http://dx.doi.org/10.1038/bjc.2013.381 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Short Communication
Beiggi, S
Johnston, J B
Seftel, M D
Pitz, M W
Kumar, R
Banerji, V
J Griffith, E
Gibson, S B
Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study
title Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study
title_full Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study
title_fullStr Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study
title_full_unstemmed Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study
title_short Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study
title_sort increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a canadian population-based study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778273/
https://www.ncbi.nlm.nih.gov/pubmed/23860531
http://dx.doi.org/10.1038/bjc.2013.381
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