Cargando…

Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer

BACKGROUND: Ethnic disparities in breast cancer diagnoses and disease-specific survival (DSS) rates in the United States are well known. However, few studies have assessed differences specifically between Asians American(s) and other ethnic groups, particularly among Asian American(s) subgroups, in...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, P, Li, X, Mittendorf, E A, Li, J, Du, X L, He, J, Ren, Y, Yang, J, Hunt, K K, Yi, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778276/
https://www.ncbi.nlm.nih.gov/pubmed/23907433
http://dx.doi.org/10.1038/bjc.2013.387
_version_ 1782285085353967616
author Liu, P
Li, X
Mittendorf, E A
Li, J
Du, X L
He, J
Ren, Y
Yang, J
Hunt, K K
Yi, M
author_facet Liu, P
Li, X
Mittendorf, E A
Li, J
Du, X L
He, J
Ren, Y
Yang, J
Hunt, K K
Yi, M
author_sort Liu, P
collection PubMed
description BACKGROUND: Ethnic disparities in breast cancer diagnoses and disease-specific survival (DSS) rates in the United States are well known. However, few studies have assessed differences specifically between Asians American(s) and other ethnic groups, particularly among Asian American(s) subgroups, in women aged 18–39 years. METHODS: The Surveillance, Epidemiology, and End Results database was used to identify women aged 18–39 years diagnosed with breast cancer from 1973 to 2009. Incidence rates, clinicopathologic features, and survival among broad ethnic groups and among Asian subgroups. RESULTS: A total of 55 153 breast cancer women aged 18–39 years were identified: 63.6% non-Hispanic white (NHW), 14.9% black, 12.8% Hispanic-white (HW), and 8.7% Asian. The overall incidence rates were stable from 1992 to 2009. Asian patients had the least advanced disease at presentation and the lowest risk of death compared with the other groups. All the Asian subgroups except the Hawaiian/Pacific Islander subgroup had better DSS than NHW, black, and HW patients. Advanced tumour stage was associated with poorer DSS in all the ethnic groups. High tumour grade was associated with poorer DSS in the NHW, black, HW, and Chinese groups. Younger age at diagnosis was associated with poorer DSS in the NHW and black groups. CONCLUSION: The presenting clinical and pathologic features of breast cancer differ by ethnicity in the United States, and these differences impact survival in women younger than 40 years.
format Online
Article
Text
id pubmed-3778276
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-37782762014-09-03 Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer Liu, P Li, X Mittendorf, E A Li, J Du, X L He, J Ren, Y Yang, J Hunt, K K Yi, M Br J Cancer Epidemiology BACKGROUND: Ethnic disparities in breast cancer diagnoses and disease-specific survival (DSS) rates in the United States are well known. However, few studies have assessed differences specifically between Asians American(s) and other ethnic groups, particularly among Asian American(s) subgroups, in women aged 18–39 years. METHODS: The Surveillance, Epidemiology, and End Results database was used to identify women aged 18–39 years diagnosed with breast cancer from 1973 to 2009. Incidence rates, clinicopathologic features, and survival among broad ethnic groups and among Asian subgroups. RESULTS: A total of 55 153 breast cancer women aged 18–39 years were identified: 63.6% non-Hispanic white (NHW), 14.9% black, 12.8% Hispanic-white (HW), and 8.7% Asian. The overall incidence rates were stable from 1992 to 2009. Asian patients had the least advanced disease at presentation and the lowest risk of death compared with the other groups. All the Asian subgroups except the Hawaiian/Pacific Islander subgroup had better DSS than NHW, black, and HW patients. Advanced tumour stage was associated with poorer DSS in all the ethnic groups. High tumour grade was associated with poorer DSS in the NHW, black, HW, and Chinese groups. Younger age at diagnosis was associated with poorer DSS in the NHW and black groups. CONCLUSION: The presenting clinical and pathologic features of breast cancer differ by ethnicity in the United States, and these differences impact survival in women younger than 40 years. Nature Publishing Group 2013-09-03 2013-08-01 /pmc/articles/PMC3778276/ /pubmed/23907433 http://dx.doi.org/10.1038/bjc.2013.387 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Liu, P
Li, X
Mittendorf, E A
Li, J
Du, X L
He, J
Ren, Y
Yang, J
Hunt, K K
Yi, M
Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer
title Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer
title_full Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer
title_fullStr Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer
title_full_unstemmed Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer
title_short Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer
title_sort comparison of clinicopathologic features and survival in young american women aged 18–39 years in different ethnic groups with breast cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778276/
https://www.ncbi.nlm.nih.gov/pubmed/23907433
http://dx.doi.org/10.1038/bjc.2013.387
work_keys_str_mv AT liup comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT lix comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT mittendorfea comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT lij comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT duxl comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT hej comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT reny comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT yangj comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT huntkk comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer
AT yim comparisonofclinicopathologicfeaturesandsurvivalinyoungamericanwomenaged1839yearsindifferentethnicgroupswithbreastcancer