Tubal ligation in relation to menopausal symptoms and breast cancer risk

BACKGROUND: Local inflammation after tubal ligation may affect ovarian function and breast cancer risk. METHODS: We analysed tubal ligation, menopausal characteristics, and breast cancer risk in the Sister Study cohort (N=50 884 women). RESULTS: Tubal ligation was associated with hot flashes (hazard...

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Autores principales: Nichols, H B, Baird, D D, DeRoo, L A, Kissling, G E, Sandler, D P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778289/
https://www.ncbi.nlm.nih.gov/pubmed/23922107
http://dx.doi.org/10.1038/bjc.2013.433
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author Nichols, H B
Baird, D D
DeRoo, L A
Kissling, G E
Sandler, D P
author_facet Nichols, H B
Baird, D D
DeRoo, L A
Kissling, G E
Sandler, D P
author_sort Nichols, H B
collection PubMed
description BACKGROUND: Local inflammation after tubal ligation may affect ovarian function and breast cancer risk. METHODS: We analysed tubal ligation, menopausal characteristics, and breast cancer risk in the Sister Study cohort (N=50 884 women). RESULTS: Tubal ligation was associated with hot flashes (hazard ratio (HR) 1.09; 95% confidence interval (CI): 1.06–1.12) but not menopausal age (HR 0.99; 95% CI: 0.96–1.02). Tubal ligation did not have an impact on breast cancer overall (HR 0.95; 95% CI: 0.85–1.06), but had a suggested inverse relation with oestrogen receptor+/progesterone receptor+ invasive tumours (HR 0.84; 95% CI: 0.70–1.01), possibly because of subsequent hysterectomy/bilateral oophorectomy. CONCLUSION: Tubal ligation does not influence overall breast cancer risk.
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spelling pubmed-37782892014-09-03 Tubal ligation in relation to menopausal symptoms and breast cancer risk Nichols, H B Baird, D D DeRoo, L A Kissling, G E Sandler, D P Br J Cancer Short Communication BACKGROUND: Local inflammation after tubal ligation may affect ovarian function and breast cancer risk. METHODS: We analysed tubal ligation, menopausal characteristics, and breast cancer risk in the Sister Study cohort (N=50 884 women). RESULTS: Tubal ligation was associated with hot flashes (hazard ratio (HR) 1.09; 95% confidence interval (CI): 1.06–1.12) but not menopausal age (HR 0.99; 95% CI: 0.96–1.02). Tubal ligation did not have an impact on breast cancer overall (HR 0.95; 95% CI: 0.85–1.06), but had a suggested inverse relation with oestrogen receptor+/progesterone receptor+ invasive tumours (HR 0.84; 95% CI: 0.70–1.01), possibly because of subsequent hysterectomy/bilateral oophorectomy. CONCLUSION: Tubal ligation does not influence overall breast cancer risk. Nature Publishing Group 2013-09-03 2013-08-06 /pmc/articles/PMC3778289/ /pubmed/23922107 http://dx.doi.org/10.1038/bjc.2013.433 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Short Communication
Nichols, H B
Baird, D D
DeRoo, L A
Kissling, G E
Sandler, D P
Tubal ligation in relation to menopausal symptoms and breast cancer risk
title Tubal ligation in relation to menopausal symptoms and breast cancer risk
title_full Tubal ligation in relation to menopausal symptoms and breast cancer risk
title_fullStr Tubal ligation in relation to menopausal symptoms and breast cancer risk
title_full_unstemmed Tubal ligation in relation to menopausal symptoms and breast cancer risk
title_short Tubal ligation in relation to menopausal symptoms and breast cancer risk
title_sort tubal ligation in relation to menopausal symptoms and breast cancer risk
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778289/
https://www.ncbi.nlm.nih.gov/pubmed/23922107
http://dx.doi.org/10.1038/bjc.2013.433
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